نتایج جستجو برای: insulin secretion.
تعداد نتایج: 295833 فیلتر نتایج به سال:
isolation of rat islets of langerhans was carried out by using collagenase and the destruction of exocrine tissue was performed through the injection of hanks' solution into the common bile duct. the identification of the islets was done by techniques including the use of a stereomicroscope against a black background. vital staining was done by an injection of neutral red solution through ...
Background: Glucokinase serves as a glucose sensor in pancreatic β-cells and plays a key role in glucose homeostasis and glucose-stimulated insulin secretion (GSIS). In the present study we examined the effect of glucosamine, a glucokinase inhibitor, on the pancreatic glucokinase and hexokinase activities and on insulin secretion from freshly rat pancreatic islets of Langerhans. Insulin concen...
Background: Insulin dependant Diabetes Mellitus (IDDM) is associated with a reduction in production or secretion of insulin from pancreatic Islets. On the other hand increase in insulin secretion will result in destruction of islets that will lead to Diabetes .Therefore the factors that could regulate secretion will prevent the onset of diabetes . Glucose metabolism that commences with the gluc...
Oral CDCA and UDCA have different effects on gut pancreatic hormone secretion. A single dose of increased fasting secretion the hormones GLP-1 OXM with an accompanying increase in insulin also reduced postprandial GIP secretion, which was associated insulin. In contrast, did not change or postprandially. could be beneficial to patients obesity diabetes.
objective(s):some pathologic situations such as diabetes and metabolic syndrome are associated with alternation in nitric oxide level. incidence of these condition increases with aging. on the other hand, insulin secretion is modulated by nitric oxide, and nitric oxide synthase (nos) activity is also altered in diabetes. in this study, modification in the enzyme activity associated with aging a...
Background and Aim: Selective PDE3 inhibitors, via cyclic adenosine monophosphate (cAMP) accumulation increase cardiac contraction and augment glucose-induced insulin secretion. In this study, the effects of some synthetic methylquinolinone derivatives (MC1-MC10) on glucose-induced insulin secretion in rats' isolated Langerhans islets model were investigated. Materials and Methods: After...
Background & Aims: As B. persicum is used in treatment of diabetes, we aimed to study the effect of B. persicum seeds extract on level of insulin secretion from isolated islets of langerhans in male mouse.Materials & Methods: In this experimental study, adult male mice (NMARI) weighting 20-25g were purchased. Islets of langerhans were isolated by collagenase digestion method and were divided i...
Background: Pancreatic islet transplantation is one of the most promising strategies for treating patients with type I diabetes mellitus.Objective: We aimed to assess the immunoisolation properties of the multilayer encapsulated islets using alginate-chitosan-PEG for immunoprotection and insulin secretion from the encapsulated islets induced under differe...
background leptin and adiponectin are two hormones, which are released from adipocytes in order to control energy expenditure. both hormones are also involved in glucose homeostasis through control of insulin secretion from pancreatic islets. since pdx1, pparγ, and foxm1 play important roles in islets function, it is essential to understand how these genes are regulated in the islets of langerh...
Objective(s): Arsenic, a toxic metal in drinking water and butyric acid (BA) is a free fatty acid found in many foods. These two can induce oxidative stress in some tissues. The present study investigated the protective effect of metformin against toxicity induced by Arsenic (As) and BA in isolated mice liver mitochondria and pancreatic islets. Materials and Methods: In this study, liver mitoch...
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