background: possible roles of anti-inflammatory factors as well as total antioxidative capacity in reproductive processes of women undergoing in vitro fertilization (ivf) are still being investigated and the contributions by some of them remain controversial. objective: the aim of this study is to investigate the relationship between anti-inflammatory parameters and total antioxidative capacity...

background uterine leiomyoma (uls) is the most common gynecological tumor and a significant health concern for many women .the interleukin-1 receptor antagonist (il-1ra) is a naturally occurring cytokine inhibiting interleukin- 1 (il-1) activity by binding to the il-1 receptors without signal transduction. objectives the aim of this study was to investigate the association between interleukin-1...

Interleukin-1 antagonism is a proposed biomarker and potential therapy for the delay and/or treatment of type 1 diabetes (T1D). We evaluated role circulating interleukin-1 receptor antagonist (IL-1ra) in prospectively monitored cohort T1D patients. In order to determine mechanistic association between IL-1ra T1D, we performed co-localization analyses serum protein quantitative trait loci genome...

Hepatocyte growth factor (HGF) prevents liver failure in various animal models including endotoxin-induced acute liver failure. We were interested to find out whether human HGF exerts anti-inflammatory effects by modulation of cytokine synthesis. Therefore, human HepG2 cells were cultured with increasing concentrations of HGF. HGF dose-dependently upregulated the production of interleukin-1 rec...

Background and objectives:  Schizophrenia is a chronic psychiatric disorder, which reduces the patient quality of life. Despite the recommendation for treating this disorder with a minimum dose of medications, antipsychotic polypharmacy has been used experimentally that cause increasing the drug interactions. Aripiprazole has low risk of metabolic has recommended as a first line a treatment fo...

Background As COVID-19 immunomodulation has been a part of interest for studies, it found that severe coronavirus disease 2019 (COVID-19) is associated with hyper-inflammatory response and increased levels interleukin-6 (IL-6) interleukin-10 (IL-10). This can progress to cytokine storm syndrome eventually development acute respiratory distress (ARDS). Interleukin-1 receptor antagonist (IL-1RA) ...

BACKGROUND There is evidence that opium addiction has immunosuppressant effects. Coronary artery disease (CAD) is a condition resulted from atherosclerosis which is dependent on the immune response. PURPOSE To evaluate plasma levels of interleukin-6 and interleukin-1Ra in 30 patients with three-vessel coronary artery disease, ejection fraction of more than 35% and to evaluate their changes af...

Interleukin-4 (IL-4) has previously been found to downregulate interleukin-1 (IL-1) production, but to upregulate the production of IL-1 receptor antagonist (IL-1ra) in human monocytes stimulated with lipopolysaccharide (LPS). In the present study we wanted to determine whether the production of IL-1ra in human monocytes and alveolar macrophages (AMs) is regulated differently at the protein and...

The cytokine channel’s mechanism for self-regulation involves the application of antagonistic cytokines that are synthesized to connect receptors and release soluble receptors. very first receptor antagonist was naturally present interleukin-1 (IL-1Ra). IL-1Ra protein forms disinfected from supernatants cultured monocytes on stacked IgG. family IL-1 consists IL-1α, IL-1β IL-1Ra. Human regulate ...

BACKGROUND The importance of the interleukin (IL)-1 cytokine family in inflammation and immunity is well established as a result of extensive in vitro and in vivo studies. In fact, much of our understanding of the in vivo importance of interleukin-1beta (IL-1B) is the result of research utilizing transgenic mice, such as overexpression or deficiencies of the naturally occurring inhibitor of IL-...