BACKGROUND The success of treatment of chronic hepatitis C (CHC) with pegylated interferon-α (PEG-IFN-α) and ribavirin (RBV) is affected by several host, viral, and treatment factors. This study was designed to describe the association of interleukin (IL) 28B genotypes for rs12979860 with sustained virologic response (SVR) in patients with genotype 1 CHC infection treated with PEG-IFN α-2 and R...

patients and methods il28b rs8099917 was genotyped in 263 patients with hepatitis c virus (hcv) infection and 244 healthy controls in tianjin, china using taqman snp genotyping method. the roles of rs8099917 and clinical characteristics in antiviral treatment were analyzed by logistic regression. results among 263 patients with chronic hcv infection, 223 had a tt genotype (84.8%). frequencies o...

background: nowadays, the immune response to hepatitis c (hcv) treatment has become a crucial issue mostly due to the interleukin 28b (il-28b) polymorphism effects in chronic hcv patients. the aim of this study was to detect the polymorphism of il-28b gene (rs12979860) in hcv genotype 1 patients treated with pegylated interferon and ribavirin. methods: from the 2010 to 2012, a total of 115 peri...

TO THE EDITOR—We read the article by Seto et al [1] with interest. The authors investigated the correlation of HLA-DP and interleukin 28B (IL-28B) polymorphisms with hepatitis B surface antigen (HBsAg) seroclearance in hepatitis B virus (HBV) patients, and found that IL-28B haplotype CG (rs12979860/rs8099917) was associated with HBsAg clearance. The role of IL-28B polymorphisms in HBV has been ...

AIM To investigate the predictability of interleukin-28B single nucleotide polymorphism rs12979860 with respect to sustained virological response (SVR) in chronically hepatitis C virus (HCV) genotype-1 patients treated with a protease-inhibitor and pegylated interferon-α (Peg-INF-α) based triple-therapy. METHODS We searched PubMed, the Cochrane Library and Web of Knowledge for studies regardi...

results the analysis of data for c/t snp showed that the cc genotype is more common in the control group than in the group of patients. in contrast, the frequency of tt as a mutant genotype is more frequent in patients than in uninfected people. in addition, results showed a statistically significant relationship between cc, ct, and tt genotypes in sensitive and resistant groups (p value: < 0.0...

Several studies have identified associations between single nucleotide polymorphisms (SNPs) occurring near the interleukin-28B (IL-28B) gene and response to antiviral treatment among hepatitis C virus (HCV) patients. Here, we describe a reliable melt-mismatch amplification mutation assay (melt-MAMA) PCR-based genotyping method for IL-28B which can be used in the management of HCV patients, help...

The cytokine interleukin-28B (IL-28B) has potential antiviral properties and regulatory roles in adaptive cellular immunity. A genome-wide association study identified a single nucleotide polymorphism near the IL-28B gene that strongly predicts response to hepatitis C treatment with interferon and ribavirin. In this study, we produced human serum albumin (HSA) fused to interleukin-28B (HSA-IL28...

BACKGROUND Feedback mechanisms between interferons α and λ (IFNs) may be affected by single nucleotide polymorphisms (SNP) in interleukin 28B (IL-28B; IFN-λ3) promoter region and may influence cytomegalovirus (CMV) replication. METHODS We associated IL-28B SNPs with the risk of CMV replication after transplantation. Next, we examined the effect of IL-28B genotypes on IL-28B, and IFN-stimulate...

Title: The association between Interleukin-28B gene polymorphisms as a potential biomarker and the risk of Chronic Periodontitis in an Iranian population Authors: Zahra Heidari ([email protected]) Bita Moudi ([email protected]) Hamidreza Mahmoudzadeh-Sagheb ([email protected]) Mehrnoosh Moudi ([email protected]) Version: 2 Date: 03 May 2017 Author’s response to reviews: HAFM-D...