BACKGROUND AND AIMS Cirrhosis (CIR) occurs in 5-7% of cystic fibrosis (CF) patients. We hypothesized that alterations in intestinal function in CF contribute to the development of CIR. AIMS Determine the frequency of macroscopic intestinal lesions, intestinal inflammation, intestinal permeability and characterize fecal microbiome in CF CIR subjects and CF subjects with no liver disease (CFnoL...

Crohn's disease (CD) is a chronic inflammatory bowel of the gastrointestinal tract. One diagnostic steps to perform magnetic resonance enterography (MRE). The purpose study was compare MRE findings with clinical index activity - CDAI score, in order verify usefullness enterography. included 46 patients who underwent according standard protocol, dynamic contrast-enhanced sequences. All studies w...

this experiment was conducted to determine the effects of sodium bentonite litter supplement and stoking density on performance and litter quality using a total of 252 broiler chicks in completely randomized design with 6 treatments which were arranged factorially (3×2) and 4 replicates. experimental factors included: stocking density (14; low and 18; high /birds per m2) and three levels of sod...

Gastric carcinogenesis (GC) is a multistep and multifactorial process the result of interplay between genetic susceptibility environmental factors. GC involves, in most cases, progression from normal mucosa through chronic gastritis, mucosal atrophy intestinal metaplasia to dysplasia neoplasia. The two diagnostic tools Operative Link on Gastritis Assessment (OLGA) Intestinal Metaplasia (OLGIM) ...

BACKGROUND Clinical and experimental research has revealed that diabetes mellitus (DM) is characterized by intestinal hypomotility, gut microbial dysbiosis, increased gut permeability, microcirculation disorders, circulatory changes, and dysfunction of intestinal stem cells, which may be linked to inflammation of intestinal mucosa. However, the relationship between type 2 DM (T2DM) and macrosco...

BACKGROUND The risk factors for necrotizing enterocolitis (NEC) are well known, but the factors involved in the different NEC presentations remain unclear. OBJECTIVES We hypothesized that digestive dysfunction and intestinal inflammation are mainly affected by severe NEC lesions. METHODS In 48 preterm pigs, the association between the macroscopic NEC score (range 1-6) and the expression of ...

The pathogenesis of nonsteroidal anti-inflammatory drug (NSAID) enteropathy is a complex process involving the uncoupling of mitochondrial oxidative phosphorylation and inhibition of cyclooxygenase (COX). Rofecoxib, a selective inhibitor of COX-2, has shown less gastric damage, but the same beneficial effect is not clear in the case of the small bowel. Fifty-seven male Wistar rats (250-350 g) w...

Minute lesions of intestinal metaplasia composed of a few metaplastic tubules were observed in the gastric mucosa during routine histological examination of gastrectomy specimens. The histological findings indicated that these lesions might be an initial stage of more advanced intestinal metaplasia. Accordingly, more than 18,000 serial sections in 10 stomachs with chronic ulcers were examined t...

Introduction. The pathogenesis of GERD is strongly related with mixed acid and bile reflux. Benign and malignant esophageal and gastric lesions have been associated with synergetic activity between those parameters. Bile reflux causes reactive gastropathy evaluated with Bile Reflux Index (BRI). The aim was to investigate if the sequence: bile reflux-intestinal metaplasia-GERD-esophagitis, is as...