Background & Objective: Meningiomas are the most frequently encountered primary non-glial tumors of the central nervous system (CNS). The Ki67 labelling index (Ki67LI) is a proliferation marker that may prove useful in determining the histological grade. This study aims at: 1) Studying the frequency, grade and histomorphological spectrum of meningiomas, 2) Evaluating 20 histolo...

During infection, Yersinia, a facultative intracellular bacterial species, exhibits the ability to first invade host cells and then counteract phagocytosis by the host cells. During these two distinct stages, invasion or antiphagocytic factors assist bacteria in manipulating host cells to accomplish each of these functions; however, the mechanism through which Yersinia regulates these functions...

introduction: squamous cell carcinoma (scc) is the most common head and neck malignancy. to decrease the side effects of treatment and mortality from disease relapse, careful staging for the proper treatment plan is necessary. the main purpose of this prospective study is to compare the diagnostic value of computed tomography (ct) and magnetic resonance im-aging (mri) in oral scc and its lymph ...

objective(s):n-myc downstream regulated gene 2 (ndrg2) is a candidate gene for tumor suppression. the expression of ndrg2 is down-regulated in several tumors including lung cancer. the aim of this study was to explore the effect of ndrg2 overexpression on invasion, migration, and enzymatic activity of matrix metalloproteinase-2 (mmp-2) and -9 (mmp-9) in human lung adenocarcinoma a549 cells.  ma...

in this issue of iranian journal of ophthalmology (irjo) han yue et al1 from china have presented a very interesting investigation on “histopathologic risk factors of retinoblastoma: a retrospective study of 104 enucleated eyes” which we are very grateful of the authors. before indicating few points about this article and their pathologic classification it is worthwhile to mention the “proceedi...

primitive neuroectodermal tumor (pnet) is usually an aggressive, rapidly progressing and metastasizing tumor. occurrence of this type of tumor in the kidney is considered as unusual and few cases have been reported so far. we present a metastatic pnet arising probably from the kidney in a 17-year-old female patient with local invasion and metastasis to the stomach. pnet should be considered as ...

Objective(s):Degradation of sphingosine 1-phosphate (S1P), as a bioactive lipid, or deregulation of its production involves in tumor progression, metastasis and chemoresistance. Since the tumor progression effects of S1P and its mechanism in chronic lymphoblastic leukemia and non-small cell lung cancer is not fully understood, we investigated the role and one of the mechanisms of S1P in tumor p...

background and objectives: the most prevalent malignancy among women is known to be breast cancer (bc). several factors contribute to determining tumor prognosis and treatment strategies. in this study, the frequency and relevance of these factors are discussed. materials and methods: this cross-sectional study was carried out on 214 patients with bc, who referred to the cancer institute of im...

purpose : to introduce a novel classification system for the extent of choroid invasion and to analyze the incidence of histopathologic risk factors (hrfs) in the patients with retinoblastoma in china methods : the clinical data of 104 enucleated eyes diagnosed with retinoblastoma were retrospectively reviewed, and the pathological re-examination of the enucleated eyes was conducted. results : ...