oxygen-derived free radical* (ofr) involvement in ischacmia-rcpcrfusion (ir) injury was investigated in a rat isolated kidney model, using 20 minutes iscliaemia followed by 15 or 60 minutes reperfusion. two antioxidants, the xanthine oxidase inhibitor allopurinol and the hydroxyl radical scavenger dimcthylthiourca (dmtu), were uscit to try and prevent ofr-relatcd damage. renal function was esti...

CORRESPONDENCE MANAGEMENT OF CARBOXYHAEMOGLOBINAEMIA Sir,—Drs Vegfors and Lennmarken have demonstrated usefully how easy it is to be misled in the management of carbon monoxide poisoning [1]. Their case deserves further comment. Unfortunately, there is little information on the mechanism of cellular toxicity of carbon monoxide. Carbon monoxide binds to haem-containing enzymes such as cytochrome...

2. Genes LS: Elcctrophysiologic Basis of Arrhythmias in Acute Myocardial Ischacmia. In Modern Trends in Cardiology, edited by MF Oliver. London, Buttcnvorths, pp 219-246, 1974 3. Case RB, Nasser MG, Crampton RS: Biochemical aspects of early myocardial ischemia. Am J Cardiol 24: 766-775, 1969 4. Parker JO, Chiong MA, West RO, Case RB The elTect of ischemia and alterations of heart rate on myocar...