laboratory-scale experiments were conducted to evaluate the joint action toxicity and biochemicaleffects of sublethal concentrations of forcados light crude oil (flco) and three dispersants against clariasgariepinus over a period of 28 days. the derived 96hrlc50 values revealed that the dispersant, ds/tt/066(0.03ml/l) was the most toxic, followed by dispersant, oc/tt/osi (0.19ml/l), flco (5.06m...

Polycyclic aromatic hydrocarbons (PAHs) typically contaminate the environment as complex assemblages of different chemical compounds. Modeling approaches provide a means of estimating the toxicity of these PAH mixtures. In the present study, we tested the hypothesis that the joint effects of four PAHs: pyrene, phenanthrene, fluoranthene and naphthalene, on the growth rate of the crustacean Daph...

This paper reviews the considerable statistical research that has been performed in an attempt to characterize the joint action of two or more chemicals from both a statistical modelling and an underlying biological mechanism point of view. Particular attention is paid to the traditional descriptions of joint toxic action, i.e. independent joint action, similar joint action, and synergistic act...

polybrominated diphenyl ethers (pbdes) have been widely used in many products as flameretardants, which resulted in their release into the environment. little is known about the impact of coexisting pbdes on organisms. in this study, the in vivo effects of bde-47 and bde-99 on a suite of biomarkers, acetyl cholinesterase (ache), ethoxyresorufin-o-deethylase (erod), glutathione-s-transferase (gs...

Examination of the available joint toxic action data, presented in Section 2.2, reveals that no health effects data are available for the complete mixture, or for ternary submixtures. Because suitable toxicity data, joint action models, and PBPK models are lacking for the complete mixture, the recommended approach for the exposure-based assessment of joint toxic action of this mixture is to use...

polybrominated diphenyl ethers (pbdes) have been widely used in many products as flameretardants, which resulted in their release into the environment. little is known about the impact of coexisting pbdes on organisms. in this study, the in vivo effects of bde-47 and bde-99 on a suite of biomarkers, acetyl cholinesterase (ache), ethoxyresorufin-o-deethylase (erod), glutathione-s-transferase (gs...

The approaches to assessing the joint action of components of a mixture are based in large measure on the conceptual groundwork laid by Bliss (1939) and Finney (1971), and are mathematical rather than biological in nature. The approaches commonly known as dose addition and response addition, discussed in the following sections, are non-interactive forms of joint action that assume the chemicals...

breeding programs strategies depends on genetical mechanism of selection traits. in the present research, generation mean analysis with joint scaling test was performed to determine the gene action. f1, f2 and f3 generations, derived from roushan and kavir cross along with their parents were sown in a partial lattice design with two replications under stress condition at the research field of s...

PREFACE The Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) mandates that the Agency for Toxic Substances and Disease Registry (ATSDR) shall assess whether adequate information on health effects is available for the priority hazardous substances. Where such information is not available or under development, ATSDR shall, in cooperation with the National Toxicology ...