The increase in oral availability of felodipine and other commonly used medications when taken with grapefruit juice has been assumed to be due to inhibition of CYP3A4, a cytochrome P450 that is present in liver and intestine. To evaluate the effect of repeated grapefruit juice ingestion on CYP3A4 expression, 10 healthy men were given 8 oz of grapefruit juice three times a day for 6 d. Before a...

Organic anion transporting polypeptides (OATPs) are a group of membrane transport proteins that facilitate the influx of endogenous and exogenous substances across biological membranes. OATPs are found in enterocytes and hepatocytes and in brain, kidney, and other tissues. In enterocytes, OATPs facilitate the gastrointestinal absorption of certain orally administered drugs. Fruit juices such as...

Chronic excessive alcohol consumption (more than 40-80 g/day for males and more than 20-40 g/day for females) could induce serious liver injury. In this study, effects of lemon juice on chronic alcohol-induced liver injury in mice were evaluated. The serum biochemical profiles and hepatic lipid peroxidation levels, triacylglycerol (TG) contents, antioxidant enzyme activities, and histopathologi...

muslims nowadays need to be present on the international stage. this involves living together with non-muslims, especially the people of the book. this sort of life and interaction has different political, cultural, economic, and military aspects. the belief that non-muslims are impure (najes) causes hardship to the muslims; and is incompatible with human dignity, which is acknowledged by the q...

Brix and apparent purity are well known to be biased estimators of dry solids and true purity respectively, particularly on lower purity streams. Correlations which estimate dry solids from brix and apparent purity and estimate true purity also from brix and apparent purity are presented. The suitability of these correlations is evaluated in the light of available historical data.

A gastric secretory depressant ;gastrone' has been previously found in normal gastric juice. These studies show that it is present in the neutralized gastric juice and is not destroyed by peptic digestion in one hour, indicating that this factor is not a protein and would be consistent with the view that it is related to the mucopolysaccharides in gastric juice.

OBJECTIVES The diversity of experimental results obtained in the study of the effect of citrus juice on urinary lithogenicity moved us to study the effect of these substances in vitro and in-vivo. The in-vitro study is based on the turbidimetric method on calcium oxalate crystallization. In vivo, we studied the effect of lemon juice consumption on urinary chemistry and we tested it on calcium o...

An in vivo study in rats showed a cranberry juice product to inhibit the intestinal first-pass metabolism of the CYP3A substrate nifedipine. However, a clinical study involving the CYP3A probe substrate midazolam and a different cranberry juice product showed no interaction. Because the composition of bioactive components in natural products can vary substantially, a systematic in vitro-in vivo...