in the present study, interactions between lead exposure with nitric oxide precursor (l-arginine) or nitric oxide synthase (nos) inhibitor (l-name) on naloxone-induced jumping and diarrhea in morphine-dependent mice were examined. chronic lead acetate (0.05%) exposure altered naloxone-induced jumping and diarrhea in mice. jumping was decreased after 7 days and was unchanged 14 and 28 days after...

Introduction: The current study aimed at investigating the role of Nitric Oxide (NO) in the maintenance of anxiety and depression induced by stress in male Wistar rats using intra-Basolateral Amygdala (BLA) injection of NO precursor, L-arginine, Nitric Oxide Synthase (NOS) inhibitor, and L-NAME.  Methods: Two 23-gauge stainless steel cannulas were placed in the BLA, stereotaxically. Seven days...

BACKGROUND This study investigates the effects of chronic administration of omapatrilat (OMA) on blood pressure (BP), renal injury, and other variables in N(omega)-nitro-L-arginine methyl ester (L-NAME) hypertension and in the low-renin model produced by the simultaneous administration of L-NAME and deoxycorticosterone acetate (DOCA). METHODS The control, DOCA, L-NAME, L-NAME + DOCA, L-NAME +...

introduction: different vasoactive factors can modulate cardiovascular adaptation to hemorrhagic shock including nitric oxide (no). in this study we investigated the effect of  the no synthase inhibitor for treatment of  decompensated hemorrhagic shock in normotensive and hypertensive rats. methods: twenty‑four male wistar rats were divided into two groups: the normotensive and hypertensive gro...

background: role of nitric oxide (no) in morphine-induced conditioned place preference (cpp) has already been proposed in the rat medial septum (ms), but no molecular evidence has been provided to clear this fact. methods: effects of intraseptal injections of l-arginine and/or ng-nitro-l-arginine methyl ester (l-name) on morphine place conditioning in wistar rats were examined. morphine (2.5-7....

in this study we investigated the effects of endothelium removal and l-name on responses to α-adrenoceptor agonists. male wistar rats were killed by overdose with pentobarbitone sodium, after which the left and right common carotid arteries were removed. rings of arteries 3-4 mm in length were cut from each vessel and then mounted in 10 ml isolated organ bath, bathed in krebs maintained at 37°c...