L1-cell adhesion molecule (L1-CAM) belongs to a functionally conserved group of neural cell adhesion molecules that are implicated in many aspects of nervous system development. In many neuronal cells the adhesive function of L1-type CAMs induces cellular signaling processes that involves the activation of neuronal tyrosine protein kinases and among other functions regulates axonal growth and g...

The L1 adhesion molecule plays an important role in axon guidance and cell migration in the nervous system. L1 is also expressed by many human carcinomas. In addition to cell surface expression, the L1 ectodomain can be released by a metalloproteinase, but the biological function of this process is unknown. Here we demonstrate that membrane-proximal cleavage of L1 can be detected in tumors and ...

Antibodies targeting the PD-1/PD-L1 immune checkpoint lead to tumor regression and improved survival in several cancers. PD-L1 expression in tumors may be predictive of response to checkpoint blockade therapy. Because tissue samples might not always be available to guide therapy, we developed and evaluated a humanized antibody for non-invasive imaging of PD-L1 expression in tumors. Radiolabeled...

This paper aims at discovering and investigating the effect of l1 translation, l1 gloss andcontext on vocabulary learning on EFL Iranian learners. A total number of 120 EFL students inprivate English institutes in Sari participated in the present study. They were divided into twoproficiency groups and three learning conditions. In order to make a list of words unknown to thelearners the partici...

OBJECTIVE Programmed death-ligand 1 (PD-L1) was expressed in various tumors and antibodies targeting its receptor programmed cell death-1 (PD-1) are emerging cancer therapeutics. This study was designed to evaluate the expression of PD-L1 and its correlation with clinicopathologic features and clinical outcomes in ovarian clear cell carcinoma (OCCC). METHODS The PD-L1 expression was measured ...

abstract the role of l1 in second/foreign language learning has been the subject of much debate and controversy. this article reports on a piece of research carried out in a junior high school in isfahan, iran. this study was conducted to examine the effect of using translation from l1 to l2 on the improvement of efl learners' language accuracy. to fulfill the purpose of the study, 62 stud...

the importance and howness of language learning/ acquisition has been a great concern for decades. there are many factors that play important roles in this regard. this research compared the performance of native persian and english elementary students to see if there is any significant difference between the two groups and which type of collocation they performed better within the groups. for ...

The human papillomavirus (HPV) capsid consists of 360 copies of the major capsid protein, L1, arranged as 72 pentamers on a T=7 icosahedral lattice, with substoichiometric amounts of the minor capsid protein, L2. In order to understand the arrangement of L2 within the HPV virion, we have defined and biochemically characterized a domain of L2 that interacts with L1 pentamers. We utilized an in v...