Lasiocarpine has been administered intragastrically to pregnant rats maintained on control and on lipotrope-deficient diets during gestation. Effects of the toxin on the maternal liver have been noted as well as the transplacental effects on the newborn rat at birth and at seven weeks postpartum. A schedule of treatment was achieved which resulted in no detectable morphologic alterations in the...

Lasiocarpine has been administered intragastrically to pregnant rats maintained on control and on lipotrope-deficient diets during gestation. Effects of the toxin on the maternal liver have been noted as well as the transplacental effects on the newborn rat at birth and at seven weeks postpartum. A schedule of treatment was achieved which resulted in no detectable morphologic alterations in the...

Helitropium europaeum L. population Garmsar was shown to contain three major alkaloids: heliotrine N-oxide (2), lasiocarpine (4) and lasiocarpine N-oxide (5); and four minor alkaloids: heliotrine (I), europine (3), acetyllasiocarpine (6) and a novel alkaloid acetyllasiocarpine N-oxide (7).

helitropium europaeum l. population garmsar was shown to contain three major alkaloids: heliotrine n-oxide (2), lasiocarpine (4) and lasiocarpine n-oxide (5); and four minor alkaloids: heliotrine (i), europine (3), acetyllasiocarpine (6) and a novel alkaloid acetyllasiocarpine n-oxide (7).

A bioassay of lasiocarpine for possible carcinogenicity was conducted by administering the test chemical in the diet to Fischer 344 rats. Groups of 24 rats of each sex were administered lasiocarpine at one of three doses, either 7, 15, or 30 ppm, for 104 weeks. Matched controls consisted of groups of 24 untreated rats of each sex. All surviving rats were killed at 104 weeks. Mean body weights o...

Lasiocarpine was injected i.p. into rats in doses of 7.8 mg/kg body weight (50% lethal dose of 0.1) twice weekly for 4 weeks and once a week for an additional 52 weeks. Of 18 rats that survived, 16 developed tumors between weeks 60 and 76 after the beginning of the experiment. Approximately 61% (11 of 18) developed hepatocellular carcinomas, and 33% (6 of 18) developed well-differentiated squam...

A reverse-phase high-performance liquid chromatography method utilizing evaporative light scattering detection (ELSD) has been developed for the simultaneous detection of hepatotoxic pyrrolizidine alkaloids with and without chromophores, namely, riddelliine, riddelliine N-oxide, senecionine, senecionine N-oxide, seneciphylline, retrorsine, integerrimine, lasiocarpine and heliotrine. Pyrrolizidi...

Pyrrolizidine alkaloids are naturally occurring secondary plant metabolites mainly found in families of Asteraceae, Boraginaceae, and Fabaceae. Chemically, Pas consist a pyrrolizidine core bearing hydroxyl groups, the so-called necine base, mono- or dicarboxylic acids bound to via ester linkages. 1,2-unsaturated PAs hepatotoxic, genotoxic, carcinogenic due highly reactive pyrrolic formed by cyt...

background and objectives: the plants belonging to the genus heliotropium l. (boraginaceae) are the main sources of toxic pyrrolizidine alkaloids (pas). in the present study, we have investigated the pas of the aerial parts of heliotropium transoxanum bunge, a perennial species native to iran. methods: silica gel column chromatography and silica gel ptlc were applied for the isolation of pas pr...