Leptin plays a central role in the control of body weight and energy homeostasis, but is a pleiotropic cytokine with activities on many peripheral cell types. In this review, we discuss the interaction of leptin with its receptor, and focus on the structural and mechanistic aspects of the extracellular aspects of leptin receptor (LR) activation. We provide an extensive overview of all structura...

The leptin signal pathway relies on Janus kinase (JAK) and signal transducer/activator of transcription (STAT) proteins to propagate its signal. When leptin binds to its receptor, JAK2 is activated to phosphorylate leptin receptor and STAT3. The phosphorylated STAT3 dimerize and become capable of modulating gene expression in the nucleus. The JAK/STAT signal is modulated by a negative regulator...

Obesity is an established risk factor for breast cancer in post-menopausal women, being associated with elevated serum levels of leptin. Although overweight a common condition cat, the role leptin and its receptor feline mammary carcinoma remains unsettled. In this study, (ObR) were investigated 58 cats compared those healthy animals, as expression ObR tumor tissues. The results showed that Fre...

A study was conducted to elucidate hormonal control of leptin receptor gene expression in primary cultures of porcine hepatocytes. Hepatocytes were isolated from swine and seeded into T-25 flasks. Cultures were established in medium containing fetal bovine serum for one day and switched to serum-free medium (William's E medium and 1 ng/mL insulin) for the remainder of the 3d culture period. For...

Leptin is a pleiotropic protein best known for regulation of appetite and fat storage in mammals. While many leptin orthologs have been identified among vertebrates, an authentic leptin in birds has remained elusive and controversial. Here we identify leptin sequence from the Peregrine falcon, Falco peregrinus (pfleptin), and identify sequences from two other birds (mallard and zebra finch), an...

Abstract Introduction Individuals with obesity hypoventilation syndrome (OHS) are unable to increase ventilation match increased CO2 production (VCO2). Obstructive sleep apnea (OSA), defined by the closure of upper airway during sleep, is present in 90% OHS patients. Leptin, an adipocyte-produced hormone, acts leptin receptor (LEPRb) positive neurons and was implicated pathophysiology OSA OHS. ...

The biological functions of leptin in the human endometrial epithelium were investigated using the human endometrial epithelial cell line, HHUA. Specifically, the effects of leptin on the proliferation and apoptosis of HHUA cells induced by treatment with anti-Fas IgM or anticancer drugs were examined. RT-PCR detected the expression of four leptin receptor isoform mRNAs in the cells and flow cy...

Leptin, an adipokine synthesized mainly by non‑neuronal tissues, has been reported to contribute to the pathogenesis of neuropathic pain. It has been hypothesized that morphine tolerance and neuropathic pain share some common pathological mechanisms. The present study was designed to examine whether spinal leptin is implicated in the development of morphine antinociceptive tolerance, and whethe...

In 1969, Douglas Coleman joined the bodies of an obese and a normal mouse by a procedure called parabiosis. Days later, the normal mouse starved. Something had taken away its desire to eat [1]. It was not until almost 25 years later that the true nature of what Coleman then called "satiety factor" was revealed. In 1994, Jeffrey Friedman identified the adipocytic hormone leptin [2,3] and it was ...