Background:Leukemia is cancer of blood and bone marrow cells. In general, there are four types of leukemia: chronic myelogenous leukemia (CML), acute myeloid leukemia (AML), B-cell chronic lymphocytic leukemia (CLL) and acute lymphoblastic leukemia (ALL).  Fractal geometry can be introduced as one of the effective ways to detect this type of cancer. In this study, with introduc...

Background and Aims: DNA methyltransferase3A (DNMT3A) is necessary for the adjustment of gene expression, and the mutations in the DNMT3A gene are reported in a variety of leukemia cases. DNMT3A mutations are during cancer progression and cause poor prognosis in many leukemias. Thus, this gene can be a target for new treatments. This study aimed to examine the distribution of DNMT3A mutations i...

Background: The purpose of this study is to investigate the genotype and allele distribution MTHFR rs1801133 in Chinese population, analyze relationship between gene polymorphism risk childhood leukemia.
 Methods: Blood samples clinical data leukemia cases (n=1132) age-matched healthy controls (n=1053) were collected. Genotypes detected by PCR-RFLP. Logistic regression model was generated ...

The most common malignancy affecting children is leukemia, which in infants refers to be diagnosed before 1 year of age and relatively rare, but remains a problem for clinicians due its aggressive clinical presentation, poor response current treatments, molecular biology. Infants with acute leukemia tend present features, including hyperleukocytosis, hepatosplenomegaly, central nervous system (...

Abstract CD4 T cell exhaustion is associated with relapse in B leukemia (B-ALL) patients. However, checkpoint blockade not effective treating B-ALL. Using a murine model of B-ALL, we demonstrate that induced cells had unique regulatory-cytotoxic phenotype (T rctx) preferential expression markers (PD1/TIM3) as well IL10 and c-Maf, which are immunosuppressive Tr1 cells. Leukemia acting APCs elici...

background: oral manifestations are frequently the initial signs of acute leukemia, prompting the patient to consult the dentist first. the gingival tissue is one site commonly involved either by leukemic infiltration or by inflammatory reactive hyperplasia, causing gingival enlargement. the gingival infiltration may also be present without gingival enlargement. early recognition of clinical fi...

T-Cell Acute Lym-phoblastic Leukemia In article number 2205854, Jingjing Ye, Min Ji, Chunyan and co-workers observed aberrant adipogenesis in the bone marrow of chemotherapy-treated T-cell acute lymphoblastic leukemia (T-ALL) patients, differentiated-adipocytes attract support residual T-ALL cells. Last, an SREBF1 inhibitor demonstrates superior improvement on therapeutic effect dexamethason by...

background: acute lymphoblastic leukemia (all) is the most common subtype of childhood cancer. chromosomal ab­normality, specially the replacement of chromosomal material is one of the main reasons in generating leukemia, wherein the kind of translocation play a key role in managing the remedy. the goal of the present study was to develop a reliable, rapid, and cost effective method to detect t...

Leukemia is a malignant disease and belongs in broader sense to Cancers. There are many types of leukemia, each which requires specific treatment. almost one-third all cancer deaths children young people. The most common type leukemia acute lymphoblastic (ALL). In this paper, new approach implanted on ALL database. For the method wavelet transform used for feature extraction, gray level co-occu...

Clinically significant myocardial infiltration by blast cells is a rare occurrence in acute leukemia. Heart failure rate children with hemato-oncological diseases unknown. Here we report clinical case of an 8-year-old female patient B-cell lymphoblastic leukemia as well heart that resolved during specific therapy for the cancer. The patient's parents gave consent to use their child's data, incl...