introduction: cytokines are a large group of proteins play a key role in inflammation. down-regulation of pro-inflammatory cytokines has beneficial effect on heart function. propranolol, as a non selective beta-adrenergic blocker, has been extensively used for treatment of many cardiovascular problems such as arrhythmias and heart malfunction. in addition anti-inflammatory effects of propranolo...

conclusions parental functioning and wellbeing are important aspects of a family adaptation to chronic pediatric conditions. moreover, psychological interventions were recommended to patients. results the abbreviation (gsi) score in leukemic children’s mothers was higher than t1dm children’s mothers and both groups had higher gsi compared with the control group. background parents’ psychologica...

Background: Dimethyl Sulfoxide (DMSO) is a solvent most broadly used as a cryopreservative agent. Antitumor effects of DMSO is a recently recognized phenomenon. In this study, cytotoxic effects of DMSO on human monocytes and T leukemic cell lines has been investigated in vitro. Methods: Human leukemic T cells (Molt-4 and Jurkat) and monocytes (U937 and THP1) were cultured in complete RPMI medi...

objective(s): artemisia is a genus of herbs and small shrubs forms an important part of natural vegetation in iran. it has been reported that several artemisia species possess anti-proliferative effects. considering the value of this genus in anti-cancer researches we have chosen artemisia biennis for cytotoxic and mechanistic studies. materials and methods:in this study we have investigated th...

objective: polymorphism of the size of heterochromatin region of chromosomes has been well documented in human genome and it consists of dna sequences that are not transcribed. the prime aim of the present study was to evaluate the heterochromatin polymorphism associated with chromosomes in leukemic patients. materials and methods: the study was conducted on 35 consecutive leukemic patients and...

Abstract Acute Myeloid Leukemia (AML) is the abnormal differentiation of hematopoietic stem cells in bone marrow into malignant blasts. The leukemic environment plays an important role during disease progression, by shaping immune landscape interacting with these Mounting evidence suggests neutrophils are complicit within tumors enhancing tumorigenesis and immunosuppression; however, little kno...

Herein we describe a case of intraocular melanoma in a17-year old leukemic patient.  The history, histological findings of the enucleated eye, blood and bone marrow of the patient were investigated. The enucleated eye contained epitheloid cell type melanoma instead of leukemic cell infiltration.  We conclude that intraocular malignant melanoma can occur in acute lymphoblastic leukemia.

herein we describe a case of intraocular melanoma in a17-year old leukemic patient.   the history, histological findings of the enucleated eye, blood and bone marrow of the patient were investigated. the enucleated eye contained epitheloid cell type melanoma instead of leukemic cell infiltration.  we conclude that intraocular malignant melanoma can occur in acute lymphoblastic leukemia.

Background: Leukemia is one of the most occurring haematological pathologies in world which develops due to impairment hematopoietic machinery. Cellular death via apoptosis severely impaired this pathophysiological condition and leads progression disease. Objective: We have tried unearth efficacy Withanolide D, a steroidal lactone derived from Withania somnifera or Ashwagandha on some apoptotic...