the objective of this work was to develop and evaluate the levofloxacin hemihydrate floating formulations (f1-f9). selection of optimized batch was done by model dependent approach and novel mathematical approach. f1-f9 batches were prepared by direct compression method using gelucire 43/01 (hydrophobic) and hydroxypropylmethylcellulose (hydrophilic) polymer in different ratios. the floating ta...

Two simple, rapid, accurate and economical 'UV Spectrophotometry' and 'First Order Derivative' methods have been developed for determination of levofloxacin hemihydrate in bulk and tablets. In (10% v/v) acetonitrile, the lambdamax of the drug was found to be 288 nm. The same spectrum was derivatised into first order derivative, using UV probe software of instrument (Shimadzu-2450), at Deltalamb...

A simple, rapid, and accurate high-performance thin-layer chromatography (HPTLC) method is described for the simultaneous determination of levofloxacin hemihydrate and ornidazole in tablet dosage form. The method is based on the HPTLC separation of the two drugs followed by densitometric measurements of their spots at 298 nm. The separation is carried out on Merck TLC aluminium sheets of silica...

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Climara 25: 6,5 cm2 patch containing 2,04 mg of estradiol hemihydrate (corresponding to estradiol 1,97 mg). Climara 50: 12,5 cm2 patch containing 3,9 mg of estradiol hemihydrate (corresponding to estradiol 3,8 mg). Climara 75: 18,75 cm2 patch containing 5,9 mg of estradiol hemihydrate (corresponding to estradiol 5,7 mg). Climara 100: 25,0 cm2 patch containing 7,8 mg of estradiol hemihydrate (co...

The disordered-molecular-alloy phase (DMA) of ammonia hydrates [J. S. Loveday and R. J. Nelmes, Phys. Rev. Lett. 83, 4329 (1999)] is unique in that it has substitutional disorder of ammonia and water over the molecular sites of a body centred cubic lattice. Whilst this structure has been observed in ammonia di- and mono-hydrate compositions, it has not been conclusively observed in the ammonia ...

OBJECTIVE To evaluate by survey the comfort upon instillation of timolol hemihydrate compared to timolol maleate with potassium sorbate. DESIGN A prospective, multicenter, observational, non-interventional study. PARTICIPANTS One hundred and three patients of open-angle glaucoma or ocular hypertension who were ≥21 years old and were currently prescribed timolol hemihydrate (once or twice da...

The present study was carried out to develop an oral formulation of pranlukast hemihydrate with improved dissolution and oral bioavailability using a surface-modified microparticle. Based on solubility measurements, surface-modified pranlukast hemihydrate microparticles were manufactured using the spray-drying method with hydroxypropylmethyl cellulose, sucrose laurate, and water and without the...

AIM To evaluate the clinical and radiological response of primary molars to direct pulp capping with calcium sulfate hemihydrate. MATERIALS AND METHODS Forty primary molar teeth in 40 healthy children aged 5-9 years were treated by direct pulp capping. Teeth were randomly assigned to two groups (n=20) according to material used for capping, as follows: Group 1: calcium hydroxide cement (Dycal...