نتایج جستجو برای: lfa

تعداد نتایج: 2358  

ژورنال: :تحقیقات مرتع و بیابان ایران 2009
پیمان لطفی اناری غلامعلی حشمتی

استفاده از روشهای نوین پایش اکوسیستم­های مرتعی از ضروریات مطالعات اکولوژیک است. یکی از روشهای نوین پایش اکوسیستم مرتعی، روش lfa می باشد که پایه­ریزی اصول و عوامل ارزیابی سطح خاک این روش منطبق با شرایط اکولوژیک کشور استرالیا صورت گرفته است. هدف از این مطالعه ارائه lfa تطبیق داده شده در یک اکوسیستم مرتعی خشک واقع در ناحیه مرکزی ایران با متوسط بارندگی سالیانه 188 میلی­متر می­باشد. در روش lfa، به م...

استفاده از روشهای نوین پایش اکوسیستم­های مرتعی از ضروریات مطالعات اکولوژیک است. یکی از روشهای نوین پایش اکوسیستم مرتعی، روش LFA می‌باشد که پایه­ریزی اصول و عوامل ارزیابی سطح خاک این روش منطبق با شرایط اکولوژیک کشور استرالیا صورت گرفته است. هدف از این مطالعه ارائه LFA تطبیق داده شده در یک اکوسیستم مرتعی خشک واقع در ناحیه مرکزی ایران با متوسط بارندگی سالیانه 188 میلی­متر می­باشد. در روش LFA، به م...

Journal: :The Journal of clinical investigation 1986
S J Mentzer B E Bierer D C Anderson T A Springer S J Burakoff

The involvement of the lymphocyte function-associated antigen-1 (LFA-1) membrane molecule in cytolytic T lymphocyte (CTL) interactions with lymphoid target cells was investigated using CTL clones derived from two patients with a heritable deficiency of LFA-1. LFA-1 surface expression on the CTL clones was 1% of the normal level of LFA-1, unchanged with prolonged culture, and identical on 14 dif...

Journal: :Journal of immunology 1989
F Rousset M Billaud D Blanchard C Figdor G M Lenoir H Spits J E De Vries

LFA-1 and LFA-3 expression is absent or low on Burkitt's lymphoma cell lines and low on the EBV-transformed B cell line UD61. Incubation of cells of BL2 and of UD61 with various concentrations of IL-4 resulted in induction of LFA-1 and LFA-3 expression in a dose dependent fashion. This effect was already observed after 16 h of incubation whereas maximal expression was obtained after 72 h. Induc...

Journal: :Journal of cell science 2000
D A Bleijs M E Binnerts S J van Vliet C G Figdor Y van Kooyk

Although ICAM-3 is implicated in both adhesion and signal transduction events of leukocytes, its low affinity for LFA-1 compared to other ligands of LFA-1 has puzzled many investigators. Here we investigated the role of ICAM-3 in supporting LFA-1-mediated ICAM-1 binding and subsequently cell signaling. We observed that although ICAM-3 binds poorly to LFA-1 expressed on resting T cells, it speci...

Journal: :Journal of immunology 1988
M E Sanders M W Makgoba S O Sharrow D Stephany T A Springer H A Young S Shaw

Studies of cell-surface molecules involved in human T cell interaction reveal that differential expression of each of three adhesion molecules (LFA-3, CD2, and LFA-1) subdivides human peripheral blood T cells into major subpopulations. Systematic analysis of the relationship between expression of these and other markers of T cell subsets demonstrates a single major subset of human peripheral bl...

Journal: :Blood 1990
M Billaud F Rousset A Calender M Cordier J P Aubry V Laisse G M Lenoir

Lymphocyte function-associated antigens 1 and 3 (LFA-1, LFA-3) and intercellular adhesion molecule 1 (ICAM-1) are cell surface adhesion molecules necessary for immune processes requiring intercellular contact. It was recently proposed that malignant Burkitt's lymphoma cells (BL) may escape from immunosurveillance through the downregulation of LFA-1 (CD11a/CD18) or LFA-3 (CD58) and ICAM-1 (CD54)...

Journal: :Chemosensors 2023

Lateral flow assay (LFA) is emerging as one of the most popular paper-based biosensors in field diagnostic industry. LFA fills all gaps between diagnosis and treatment it provides beneficial qualities to users such quick response, Point-of-care appeal, early detection, low cost, effective sensitive detections various infectious diseases. These benefits increase LFA’s dependability for disease m...

2016
Christina Eich Edwin Lasonder Luis J. Cruz Inge Reinieren-Beeren Alessandra Cambi Carl G. Figdor Sonja I. Buschow Fabrizio Mattei

The β2-integrin lymphocyte function-associated antigen 1 (LFA-1) plays an important role in the migration, adhesion and intercellular communication of dendritic cells (DCs). During the differentiation of human DCs from monocyte precursors, LFA-1 ligand binding capacity is completely lost, even though its expression levels were remained constant. Yet LFA-1-mediated adhesive capacity on DCs can b...

Journal: :The Journal of biological chemistry 2009
Yang Wang Dan Li Roza Nurieva Justin Yang Mehmet Sen Roberto Carreño Sijie Lu Bradley W McIntyre Jeffrey J Molldrem Glen B Legge Qing Ma

The activation of LFA-1 (lymphocyte function-associated antigen) is a critical event for T cell co-stimulation. The mechanism of LFA-1 activation involves both affinity and avidity regulation, but the role of each in T cell activation remains unclear. We have identified antibodies that recognize and block different affinity states of the mouse LFA-1 I-domain. Monoclonal antibody 2D7 preferentia...

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