Background: Transient elastography (TE) is a new modality for the diagnosis of liver fibrosis caused by various etiologies. This study was conducted to determine the accuracy of TE in detecting the different stages of liver fibrosis in non-alcoholic fatty liver disease (NAFLD) patients. Methods: MEDLINE/PubMed, Embase, Ovid, Cochrane Library, American College of Physicians (ACP) Journal Club...

conclusions m30 levels were higher in cvhb patients compared to healthy controls. however, m30 levels were similar in the mild and moderate stages of fibrosis, so they did not indicate the severity of underlying fibrotic or inflammatory processes in cvhb patients. results the mean ages of patients and controls were 39.7 and 45.7 years, respectively, and 35% of the controls and 52% of the patien...

conclusions patients with chronic hepatitis c and with a ciscun ≤ 1 had a very low rate of cirrhosis while those with a ciscun = 4 had a high risk of cirrhosis. patients with ciscun = 2 or 3 had an intermediate rate of cirrhosis, and therefore needed to perform a liver biopsy to receive a reliable diagnosis. results we enrolled 249 patients who had complete laboratoristic data, and sufficient l...

background this prospective study was designed to examine the role of fibrosis staging on selection and success of treatment options for autoimmune hepatitis (aih). materials and methods the project was conducted on 110 selected aih patients who, based on the results of liver biopsy, had been assigned into one of the three groups (mild, stages 1 and 2, moderate, stages 3 and 4, and severe, stag...

aim : in this study, to clarify the smad4blocking impact on fibrosis process, we investigated its down-regulation by shrna on activated human lx-2 cell, in vitro.   background : liver fibrosis is a critical consequence of chronic damage to the liver that can progress toward advanced diseases, liver cirrhosis and hepatocellular carcinoma (hcc).  different smad proteins play as major mediators in...

Background: Bone marrow-derived mesenchymal stem cells (BMMSCs) transplantation has been considered as a promising milestone in liver fibrosis treatment. However, low amounts of homing are a major obstacle. We aimed to investigate the role of melatonin pretreatment in BMMSC homing into experimental liver fibrosis. Methods: BMMSCs were obtained, grown, propagated and preconditioned with 5 &micro...

background nonalcoholic fatty liver disease (nafld) is being increasingly recognized as a cause of chronic liver disease. it has also been associated with devastating outcomes such as decompensated liver cirrhosis and hepatocellular carcinoma, as well as diabetes and metabolic syndrome. objectives this study was conducted in order to assess liver fibrosis using fibroscan, and to compare these r...

conclusions il6 and il8 gene polymorphisms have no role in nash pathogenesis and liver fibrosis process, but presence of the a/a genotype in the il8 gene is associated with disease progression. patients and methods consecutive patients with biopsy proven nash and age- and gender-matched healthy individuals with normal liver function tests and normal ultrasonography were enrolled in the study. h...