Docking, the initial association of secretory vesicles with the plasma membrane, precedes formation of the SNARE complex, which drives membrane fusion. For many years, the molecular identity of the docked state, and especially the vesicular docking protein, has been unknown, as has the link to SNARE complex assembly. Here, using adrenal chromaffin cells, we identify the vesicular docking partne...

this paper has been offered a technique for proper locating of taliya company’s sales shops and the supporting service centers. the researcher has discussed to know the related fundamental elements through library researches, interviews with taliya professionals which are classified in two main categories of attributes and constraints. the attributes are consisting of marketing & customer’s sat...

The necessity of treating receptor flexibility in proteinligand docking has been widely acknowledged and is the subject of extensive research in the field of drug discovery [1]. The use of multiple discrete protein conformations, so-called ensemble docking, has been proven to be a valid concept to mimic target plasticity in docking experiments [2,3]. Using molecular dynamics (MD) the number of ...

conclusions our data provided information on the prevalence and types of intraosseous lesions among an iranian population. this study provided baseline information to help in designing and programming procedures in health care centers in every community so that preventive therapeutic measures can be adopted. patients and methods this cross-sectional descriptive analytical study was carried out ...

Integrating Dock-Door Assignment and Vehicle Routing in Cross-Docking

the inappropriate space distribution of rural services causes many problems, including loss of adoptness, and unfair distribution of services according to the existing capacities. in this research, the studied region is “dehdez” zone of “izeh” province,”khuzestan” state. the goal of the present paper is to prpvide an optimal and ideal location finding of rural services centers in dehdez zone, i...

in the field of health losses resulting from failure to establish the facilities in a suitable location and the required number, beyond the cost and quality of service will result in an increase in mortality and the spread of diseases. so the facility location models have special importance in this area. in this paper, a successively inclusive hierarchical model for location of health centers i...