objective(s): abnormal lung cell death including autophagy and apoptosis is the central feature in acute lung injury (ali). to identify the cellular mechanisms and the chronology by which different types of lung cell death are activated during lipopolysaccharide (lps)-induced ali, we decided to evaluate autophagy (by lc3-ii and autophagosome) and apoptosis (by caspase-3) at different time point...

bronchial responsiveness to bronchodilator medications is usually tested to establish reversibility of airflow obstruction. among the various tests to establish bronchodilator response, fev1, fef25-75% or fef50%, and fvc are the most widely used. in a cross-sectional study, we assessed spirometric responses after administration of bronchodilator in 187 workers with obstructive pattern in spirom...

we describe a patient with newly diagnosed limy cancer. staging was performed with ct and mediastinoscopy. fdg pet scan was performed and confirmed increased metabolic activity in the primary tumor as well as the hilar lymph node. seven months after initial presentation, the patient was found to have two lytic lesions in the pelvis on plain radiograph. hone scan was negative but pet demonstrate...

background: the objective of this study is to assess the safety and preventative effects of aminophylline on the incidence of chronic lung disease (cld) in very premature infants. methods: this was a long follow‑up randomized clinical trial. the prophylactic effect of aminophylline on the incidence of cld was investigated in very premature infants. the study group received aminophylline for the...

there are evidences that statins have anti-inflammatory effects beyond their cholesterol lowering properties. the study was conducted to assess the effects of atorvastatin on asthma as an inflammatory disease. patients with moderate to severe asthma were entered this randomized, double blind, crossover clinical trial. the impact of oral atorvastatin (10 mg/day) on the lung function of normolipi...

Introduction: Pulmonary involvement secondary to Systemic Sclerosis (SSc) is the major cause of morbidity and mortality in SSc patients. We designed this study to determine the correlation of important lung function parameters with lung High Resolution CT (HRCT) scan findings. Materials and Methods: Thirty–two consecutive diffuse SSc patients with pulmonary fibrosis were enrolled in this cross...

sulfur mustard (sm) has been identified as an important chemical weapon. during the iran-iraq war of 1980-88, the extensive usage of sm against iranian civilians and military forces was proven. this agent has been shown to cause severe damage mainly in the skin, eyes, lungs,  and  respiratory  tract  in  iranian  veterans.  the  most  common  disease  is bronchiolitis obliterans (bo)). sm incre...

objective mustard gas (mg) is a poisoning chemical, mutagenic and carcinogenic alkylating agent. it is used during world war i and also iran-iraq conflict. the p53 tumor suppressor gene is involved in the pathogenesis of malignant disease. the aim of this study is to determine possible mutation in p53 gene of lung sample from mustard gas exposed patients. material and methods twelve lung biopsy...

introduction: although extensive research has been conducted on lung cancer markers, a singular clinically applicable marker has not been found yet. the objective of this study was to evaluate the sensitivity and the specificity of carcinoembryonic antigen (cea) mrna and lung-specific x protein (lunx) mrna biomarkers in peripheral blood to detect lung cancer individually and simultaneously. met...