نتایج جستجو برای: lymphoblastoid cell lines (lcls)

تعداد نتایج: 1795585  

Journal: :iranian journal of allergy, asthma and immunology 0
mahmood mahmoodian shooshtari suzan finerty rew john morgan

the aim of this work was to see whether tamarin immunisation with recombinant vaccinia virus expressing epstein barr virus latent proteins could prime t cells which were, on activation, able to inhibit the outgrowth of epstein barr virus transformed cells in vitro. the vaccination appeared to be successful as all vaccinated tamarins developed vaccinia lesions. however, the vaccination protocol ...

Obtaining a continuous source of normal cells or DNA from a single individual has always been a rate limiting step in biomedical research. Availability of Lymphoblastoid cell lines (LCLs) as a surrogate for isolated or cryopreserved peripheral blood lymphocytes has substantially accelerated the process of biological investigations. LCLs can be established by in vitro infection of resting B cell...

2012
Tabish Hussain Ashwin Kotnis Rajiv Sarin Rita Mulherkar

BACKGROUND & OBJECTIVES A major drawback for genetic studies as well as long-term genotype-phenotype correlation studies in cancer is lack of representative human cell lines providing a continuous source of basic biomolecules and a system to carry out various experimental investigations. This can be overcome to some extent by establishing lymphoblastoid cell lines (LCLs) by infecting peripheral...

Journal: :international journal of molecular and cellular medicine 0
rita mulherkar actrec, tata memorial centre, kharghar, navi mumbai, india. tabish husain actrec, tata memorial centre, kharghar, navi mumbai, india.

obtaining a continuous source of normal cells or dna from a single individual has always been a rate limiting step in biomedical research. availability of lymphoblastoid cell lines (lcls) as a surrogate for isolated or cryopreserved peripheral blood lymphocytes has substantially accelerated the process of biological investigations. lcls can be established by in vitro infection of resting b cell...

AD WILSON, AJ MORGAN, M MAHMOUDIAN SHOOSHTARI, P WATKIN, S FINERTY,

EBV-carrying human cell lines, depending on whether the cells are derived from Burkitt's lymphoma (BL) tumor biopsies or transformed by EBV in vitro, have different growth properties in vitro. In contrast, there are no clear differences between tamarin tumor lines and tamarin LCLs in vitro. Both types of tamarin cell lines could grow in agarose and formed colonies unlike human LCLs, althoug...

Journal: :medical journal of islamic republic of iran 0
m mahmoudian shooshtari from the iranian blood transfusion organization, tehran, i.r. iran ad wilson the department of pathology p watkin the department of pathology s finerty the department of pathology aj morgan the department of pathology

ebv-carrying human cell lines, depending on whether the cells are derived from burkitt's lymphoma (bl) tumor biopsies or transformed by ebv in vitro, have different growth properties in vitro. in contrast, there are no clear differences between tamarin tumor lines and tamarin lcls in vitro. both types of tamarin cell lines could grow in agarose and formed colonies unlike human lcls, althou...

Journal: :Experimental oncology 2014
L M Shlapatska L M Kovalevska I M Gordiienko S P Sidorenko

BACKGROUND X-linked lymphoproliferative disease type 1 (XLP1) belongs to genetically determined primary immunodeficiency syndromes with mutations in SH2D1A/DSHP/SAP gene. The dramatic increase of the risk of B-cell lymphoma development in XLP1 patients is linked not only to SAP deficiency of NK, NKT and T cells, but probably to the impairment of B cell differentiation. AIM To analyze the rece...

2014
Minal Çalışkan Jonathan K. Pritchard Carole Ober Yoav Gilad

Epstein-Barr virus (EBV) transformed lymphoblastoid cell lines (LCLs) are a widely used renewable resource for functional genomic studies in humans. The ability to accumulate multidimensional data pertaining to the same individual cell lines, from complete genomic sequences to detailed gene regulatory profiles, further enhances the utility of LCLs as a model system. However, the extent to which...

Journal: :The Journal of general virology 2007
James McLaren Martin Rowe Paul Brennan

Since 'constitutive activation' of STAT1 was first described in Epstein-Barr virus (EBV)-immortalized lymphoblastoid cell lines (LCLs), there has been controversy regarding the molecular identity of the STAT1 DNA-binding complex found in these cells. The post-translational modifications of STAT1 in LCLs have been analysed and an LMP1-induced STAT1 DNA-binding complex, different from that genera...

Journal: :Human molecular genetics 2011
Minal Caliskan Darren A Cusanovich Carole Ober Yoav Gilad

Epstein-Barr virus (EBV) transformed lymphoblastoid cell lines (LCLs) provide a conveniently accessible and renewable resource for functional genomic studies in humans. The ability to accumulate multidimensional data pertaining to the same individual cell lines, from complete genomic sequences to detailed gene regulatory profiles, further enhances the utility of LCLs as a model system. A linger...

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