tuberculosis is a chronic mycobacterial infection. the main effector cells against mycobacterium tuberculosis are cd4+ t lymphocytes. our objective in this research was to evaluate the quantity of t lymphocytes and their subpopulations before and after treatments with combination of 4 drugs (rifampcin, isoniaside, pyrasinamide, ethambutal) for 2 months directly in sputum-positive tuberculosis p...

bleomycin (blm)as an anti-cancer agent causes tissue toxicities through dna damaging and cell deaths. the aim of this study was to investigate the effects of thymol against genotoxicity and anti-proliferation induced by blm in normal human lymphocytes and ovarian cancer cells.peripheral blood samples were collected from human volunteers and were incubated with thymolat different concentrations ...

systemic lupus erythematosus (sle) is a chronic autoimmune disease which results in damage to various organs. some animal studies have revealed that activation of toll-like receptors (tlrs) is important in the pathogenesis of sle. in the present study, the percentage of different immune cell subsets in 35 sle patients and 38 control subjects was analyzed by flow cytometry. we also assessed the ...

down's syndrome (ds) is the most common chromosomal abnormality in human. subjects with ds are known to be peridisposed to develop leukemia. the molecular basis of the association between ds and leukemia is unknown. the unscheduled dna synthesis (uds) test measure the ability of dna-repair in mammalian cells after excision of a stretch of dna containing the region of damage induced by chem...

Contact hypersensitivity (CHS) mouse model induced by 2, 4-dinitrofluorobenzene (DNFB) is thought to be a T helper 1 (Th1)-dominant response and used for investigating anti-inflammatory and immunosuppressive agents. However, it is hardly used for screening large-scale drugs because of the large number of animals and complex mechanisms involved in-vivo. In this study, we focused on whether T lym...

Background: Radiotherapy is regarded as a standard treatment modality in breast cancer (BC). Radiation causes cellular damage both in cancer and normal cells by inducing DNA-damage and chromosomal aberrations (CA). Different agents were used for ameliorating effects of radiation, mainly antioxidants such as melatonin. Melatonin shows oncostatic properties on human BC. The aim of this study was ...

background: the aim of preliminary study was determined development process status of t-cell population lymphocytes in ukrainian children after 22 years from chernobyl accident for next feasibility study. material and method: 150 participants aged 6 to 16 years are included in three groups: group i (n=65), 30 to 60 km from center accident at zone 3th, group ii (n=65) 60 to 90 km from same locat...

objective(s)the aim of this study was to investigate the radioprotective effect of green tea against genotoxicity induced by gamma irradiation in cultured blood lymphocytes from 5 human volunteers.materials and methodsperipheral blood samples were collected from volunteers before and 1, 3 and 5 hr after drinking a decoction 4 g green tea in 280 ml boiling water for 5 constitutive days with the ...