Recently, several new urinary gonadotrophin preparations have been developed, containing less luteinizing hormone (LH) activity than human menopausal gonadotrophin. Normegon is a gonadotrophin preparation with a follicle stimulating hormone (FSH)/LH ratio of 3:1; Follegon and Metrodin-HP are purified FSH preparations. The aim of the present randomized study was to compare pharmaco-dynamics, -ki...

It is uncertain whether the abnormal findings indicate impaired liver function. It has been suggested that they may be a result of the pseudopregnancy state (Tyler, 1964). , While the B.S.P.-removal mechanisms have been found to be impaired in normal pregnancy (Combes et al., 1963), the serum-transaminase levels and the standard B.S.P. retention are not abnormal (Christhilf et al., 1950 ; Combe...

Recent papers have reported small clinical trials of progestins in combination with oestrogens in the treatment of advanced breast cancer (Landau et al., 1962 ; Stoll, 1965 ; Crowley and MacDonald, 1965). This form of combination therapy is based upon experimental observations in rats made by Huggins et al. (1962). The clinical reports to date suggest that a beneficial response may be expected ...

serum total fatty acids were estimated in controls and women using the oral contraceptives eugynon (containing 0.5 mg.of norgestron and 0.05 mg ethinyl oestradiol) and lyndiol (containing 2.5 mg. of linostrol and 0.05 mg of ethiny oestradiol) for periods ranging from 8 to 110 weeks. the serum total fatty acids level was found to be approximately 70% higher in the women using oral contraceptives...

An experiment is described which tests for visible and invisible mutants in mice treated with four different doses each of the contraceptives Gynanovlar and Lyndiol. The results show that there is no reason to suppose that either substance has an appreciable mutagenic effect, expressed as an increase of antenatal and postnatal lethals or visibles. The substrain CBA/CagCam, used throughout, has ...

Preliminary Comncain BRITISH96 hepatocellular damage was seen in all six cases biopsied, but cholestasis was seen in only two of them. In this respect our findings are in conformity with the biochemical observations of Eisalo and of Palva and Mustala, in that abnormal enzyme levels are seen more frequently than abnormal biliary excretion tests. According to Eisalo et al. the biochemical changes...

A randomized, single-centre, cross-over study was designed to compare the bioavailability of two pharmaceutical formulations of recombinant human follicle stimulating hormone (recFSH; Puregon(R)): (i) a dissolved cake injected by a normal syringe; and (ii) a ready-for-use solution injected using a device referred to as Puregon(R)Pen. Twenty-two healthy female volunteers underwent one of two adm...