Giant cell arteritis (GCA) is one of the commonest forms of vasculitis in the elderly, and may result in blindness and stroke. The pathogenesis of GCA is not understood, although environmental, infectious and genetic risk factors are implicated. One gene of interest is PTPN22, encoding lymphoid protein tyrosine phosphatase (Lyp), expressed exclusively in immune cells, which is proposed to be an...

Concentrically braced frame (CBF) systems are susceptible to buckling (which causes a decrease in energy absorption), although this system has considerable lateral stiffness and strength. To over shortcoming, researchers have suggested the use of I-shaped steel dampers as practical idea that prevents increases absorption but reduces system. increase damper, thickness web or flange can be increa...

Abstract Three new Schiff bases, (Z)-2-(4-(dimethylamino)benzylidene)-N-methylhydrazinecarbothioamide (PDM), (Z)-2-(2-hydroxy-5-nitrobenzylidene)-N-methylhydrazinecarbothioamide (5NS) and (Z)-2-(4-cyanobenzylidene)-N-methylhydrazinecarbothioamide (4CN) of thiosemicarbazone-benzaldehyde derivatives were synthesized by condensation reaction. These compounds formed from the reaction 4-methyl-3-thi...

autoimmune disease with an annual incidence of 10.5/100,000 in Asian Indians [1]. It is characterized by T cell-mediated destruction of pancreatic beta cells influenced by multiple genetic factors, such as HLA-II locus on chromosome 6p21.3 [2], insulin gene on 11p15.5 [3] and the CTLA4 locus on 2q33 [4], all of these are involved in T cell activation, immune homeostasis and development of T cel...

To improve drug selectivity toward target cells, one interesting approach for drug delivery is to use polymer nanoparticles. A two-layered ONIOM Becke3- LYP: UFF calculation was carried out to study the structural and thermodynamic properties of the interaction between acetamide derivatives and the PCA-PEG-PCA copolymers. The Interaction enthalpies and the Gibbs free energies between acetamide ...

This paper describes the seismic performance of a steel frame with additional LYP dampers. dampers provides passive energy dissipation device in structure, it also reduces lateral forces efficient way which is produced by wave. The structures needed design especially countries where activities occur. analysis accomplished FEM and software called SAP2000. only analyzed using numerical simulation...

With this work, we aimed to review the principal benign and malignant tumors (including vascular, keratinocytic/epidermal, melanocytic, hematopoietic, lymphoid origin), primarily affecting leg’s skin. The lesions’ location can also help focus on a spectrum of differential diagnoses in clinical practice. All diseases present same presentation characterized by erythematous violaceous nodules. Des...