Background and Objectives: Giant cell Tumor of bone (GCT) is often regarded as a benign tumor, but its clinical course is unpredictable, has a high rate of recurrence, and even can metastases and transform to a malignant tumor. Histological features of the tumor often could not predict its future biologic behavior, so it is just called ''Giant cell tumor'' without indicating maligna...

Introduction: There is still no finding available that can show the malignant clinical course in patients with middle cerebral artery stroke. The aim of this study was to compare Doppler ultrasound findings in patients with malignant and non-malignant middle cerebral artery stroke in order to obtain its prognostic value in detecting malignant course. Method:</stro...

background and objectives: giant cell tumor of bone (gct) is often regarded as a benign tumor, but its clinical course is unpredictable, has a high rate of recurrence, and even can metastases and transform to a malignant tumor. histological features of the tumor often could not predict its future biologic behavior, so it is just called ''giant cell tumor'' without indicating malignancy or benig...

The malignant transformation of conventional giant cell tumor of bone (GCTOB) is rare and usually occurs with irradiation. Here we report two neglected cases of conventional GCTOB with spontaneous malignant transformation at 11 and 16 years after initial diagnosis. In the former case, the patient refused to receive any treatment following the incisional biopsy, and in the latter, the firs...