twik2 ion channels (k2p6.1, encoded by a gene named kcnk6) belong to the family of two-pore domain potassium channels. twik2 is also considered as a “silent” channel because of its inability to produce measurable currents in heterologous expression systems and its intracellular retention. it is expressed in different mammalian tissues including lymphoid organs and the vascular system. however, ...

Objective(s): To benefit from reproduction and deal with challenges in the environmental conditions, animals must adapt internal physiology to maximize the reproduction rate. Maladaptive variations in the neurochemical systems and reproductive system can lead to manifestation of several significant mammalian reprocesses, including mammalian ovarian lifespan. RFamide-related peptide (RFRP, Rfrp)...

an experimental study was accomplished to compare estimation methods of ionizing radiations genotoxicity in mammalian cell cultures by means of two cytogenetic parameters with focus on aberrant cells characterized by multiple chromosomal damages.in vitro study was carried out on the genotoxicity of low-medium doses of 190 kv x-rays absorbed in chinese hamster ovary cell cultures. micronuclei an...

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This Perspectives is a review of the breathtaking history of mammalian genetics in the past century and, in particular, of the ways in which genetic thinking has illuminated aspects of mouse development. To illustrate the power of that thinking, selected hypothesis-driven experiments and technical advances are discussed. Also included in this account are the beginnings of mouse genetics at the ...

This dialogue between the Editor-in-Chief of the Int. J. Dev. Biol. and a leading figure in human pathology and mammalian embryology highlights the close links between the biological interpretation of neoplasia and differentiation processes which normally occur during development, particularly in the case of teratomas. In addition, it emphasizes how a capacity for work, a firm will to progress,...

HE events that take place in the development of the mammalian T embryo have not been subjected to an extensive causal analysis so far. The reasons for this are“to be found mainly in the lack of suitable methods. It is not possible yet to use transplantation, isolation or vital staining techniques on mammalian embryos as they have been used on amphibian embryos. In the course of time it probably...

Although eucaryotic chromosomes vary in size over five orders of magnitude and are constituents of diverse genetic systems the fundamental features of their telomeres appear to be almost completely conserved. This can be exploited to enable molecular cloning of human telomeres in yeast and suggests that many of the ideas that will arise from studies of telomeres in the experimentally tractable ...

the optimization of cell culture conditions for growth and productivity of recombinant chinese hamster ovary (cho) cells is a critical step in biopharmaceutical manufacturing. in the present study, the effects of the timing and amount of peptone feeding of a recombinant cho cell line grown in a basal medium in serum-free suspension culture were determined for eight peptones of different origin ...