In this issue of JEM, Marciniak et al. (https://doi.org/10.1084/jem.20161731) identify a putative novel function of tau protein as a regulator of insulin signaling in the brain. They find that tau deletion impairs hippocampal response to insulin through IRS-1 and PTEN dysregulation and suggest that, in Alzheimer's disease, impairment of brain insulin signaling might occur via tau loss of function.

Background: The concentration and specific activity of N-acetyl-b-hexosaminidase (HEX) in palatine tonsils with chronic tonsillitis and tonsillar hypertrophy give insight in tonsillar tissue remodeling and constitute a potential marker for diagnosis and treatment of chronic tonsillitis and tonsillar hypertrophy. Aim: Determining the concentration and specific activity of N-acetyl-b-hexosaminida...

Let 2 be ordered by set inclusion and let B ⊆ 2 be an antichain of size n := |B|. An antichain B is k-regular for some non-negative integer k, if for each i ∈ [m] there are exactly k sets B1, B2, . . . , Bk ∈ B containing i. In this case we say that B is a (k, m, n)-antichain. Let 2 ≤ k ≤ m − 2 be positive integers. In this paper we show that a (k, m, n)-antichain exists if and only if k + 1 ≤ ...