Introduction: The use of BMP-2 plays an important role in the treatment of extensive bone defect. However, data about the optimal dosage of BMP-2 in the massive bone defect cases is rare. Material and Method: Twenty-five SD rats were randomly divided into a control group ofhydroxyapatite (HA) alone (Group I), HA+BMP-2 1µg/mL (Group II), HA+BMP-2 5 ug/mL (Group III), HA+BMP-2 10 µg/mL (Gro...

A case of massive osteolysis of the skull and its histology is described. Removal of the bone defect with a margin of normal bone and covering of the defect by cranioplasty is advised and may arrest the disease.

BACKGROUND Massive bone defects of the acetabulum with pelvic discontinuity are one of the major problems in revision total hip arthroplasty. Several techniques have been described for repair of acetabular defect; however, reconstruction of acetabulum with massive bone defect is still a major problem. We describe a patient who required four revision total hip arthroplasty during a 24-year perio...

INTRODUCTION Tibia fracture caused by high velocity missiles is mostly comminuted and followed by bone defect which makes their healing process extremely difficult and prone to numerous complications. CASE OUTLINE A 34-year-old male was wounded at close range by a semi-automatic gun missile. He was wounded in the distal area of the left tibia and suffered a massive defect of the bone and soft...

We report the histological findings of a reconstructed calcar region four years after femoral impaction bone grafting using metal wire mesh for a case with massive defect of the proximal part of the femur. Thin cortical bone was formed just beneath the metal wire mesh and viable trabecular bone containing a small amount of granulation tissue was observed even at the bone-cement interface. Almos...

parotid stafne bone defect is a very rare and infrequent variant, which is located on the buccal or lingual surface of the mandibular ascending ramus. in this paper, a case of parotid stafne defect, which was incidentally discovered during dental radiographic examination, is reported. this bone defect was observed as a lucent oval-shaped defect on the lingual aspect of the right mandibular ramu...