a controlled release matrix formulation for mesalamine was designed and developed to achieve a 24 h release profile. using compritol 888 ato (glyceryl behenate) as an inert matrix-forming agent to control the release of mesalamine, formulation granules containing the solid dispersions were investigated. pectin, a polysaccharide, was used as bacterial dependent polymer for colon targeting. the m...

The study was carried out to investigate the drug release profiles of multi-unit dosage formulations of theophylline consisting of both the fast and slow release components in a unit dose. The fast release component consisted of conventional granules of theophylline formed by mixing the drug powder with starch mucilage (20% w/v) while the slow release component consisted of wax granulations of ...

In this work, starch acetate and propanoate derivatives with moderate degree of substitution were synthesized and characterized for employment as matrix formers for sustained release from tablets. Matrix tablets were prepared from cospray-dried and simple physical mixtures of starch/starch derivatives and theophylline as a model drug. The release was rapid for matrix tablets prepared from simpl...

The present investigation deals with the development of controlled release tablets of salbutamol sulphate using graft copolymers (St-g-PMMA and Ast-g-PMMA) of starch and acetylated starch. Drug excipient compatibility was spectroscopically analyzed via FT-IR, which confirmed no interaction between drug and other excipients. Formulations were evaluated for physical characteristics like hardness,...

Magnetic manipulation of capsule endoscopes has the potential to make current gastrointestinal screening procedures faster, safer, and less invasive. To date, two electromagnetic systems have been developed with the ability to perform five-degree-of-freedom (5-DOF) manipulation of an untethered magnetic device such as a magnetic capsule endoscope: the OctoMag system consists of eight electromag...

In this study, an investigate effect of moisture absorption by ranitidine and resinates used to improve stability of ranitidine hydrochloride tablets. Moisture absorption by ranitidine at three different level of relative humidity (RH) has been studied. Percentage of moisture absorption at 22% was low as compared to 57% and 75% RH. To eliminate deliquescent tendency of drug, weak cation-exchang...

Purpose: To develop an oral capsule-based chronomodulated drug delivery system of salbutamol sulphate for the treatment of nocturnal asthma. Methods: The basic design of the proposed dosage form entails an insoluble cross-linked capsule body filled with drug-loaded pellets sealed with hydrocolloid plug and a soluble capsule cap. Various hydrocolloid polymers, namely, hydroxypropyl methylcellulo...