نتایج جستجو برای: mcm

تعداد نتایج: 3500  

2012
Tin Nguyen Madhav Jagannathan Kathy Shire Lori Frappier

MCM-BP was discovered as a protein that co-purified from human cells with MCM proteins 3 through 7; results which were recapitulated in frogs, yeast and plants. Evidence in all of these organisms supports an important role for MCM-BP in DNA replication, including contributions to MCM complex unloading. However the mechanisms by which MCM-BP functions and associates with MCM complexes are not we...

Journal: :Journal of cell science 2012
Madhav Jagannathan Amos M Sakwe Tin Nguyen Lori Frappier

Mini-chromosome maintenance complex-binding protein (MCM-BP) was discovered as a protein that is strongly associated with human MCM proteins, known to be crucial for DNA replication in providing DNA helicase activity. The Xenopus MCM-BP homologue appears to play a role in unloading MCM complexes from chromatin after DNA synthesis; however, the importance of MCM-BP and its functional contributio...

2017
Jordi Frigola Jun He Kerstin Kinkelin Valerie E Pye Ludovic Renault Max E Douglas Dirk Remus Peter Cherepanov Alessandro Costa John F X Diffley

ORC, Cdc6 and Cdt1 act together to load hexameric MCM, the motor of the eukaryotic replicative helicase, into double hexamers at replication origins. Here we show that Cdt1 interacts with MCM subunits Mcm2, 4 and 6, which both destabilizes the Mcm2-5 interface and inhibits MCM ATPase activity. Using X-ray crystallography, we show that Cdt1 contains two winged-helix domains in the C-terminal hal...

Journal: :Molecules 2014
Sana Alahmadi Sharifah Mohamad Mohd Jamil Maah

The adsorption of tributyltin (TBT), onto three mesoporous silica adsorbents functionalized with calix[4]arene, p-tert-butylcalix[4]arene and p-sulfonatocalix[4]arene (MCM-TDI-C4, MCM-TDI-PC4 and MCM-TDI-C4S, respectively) has been compared. Batch adsorption experiments were carried out and the effect of contact time, initial TBT concentration, pH and temperature were studied. The Koble-Corriga...

Journal: :The Journal of nutrition 1987
M D Finke G R DeFoliart N J Benevenga

Weanling Sprague-Dawley rats were fed diets containing corn gluten meal (CGM), Mormon cricket meal (MCM), MCM supplemented with methionine (MCM + Met) or CGM-MCM mixtures as the sole source of dietary protein in purified diets. Animal response (weight or nitrogen gain) was analyzed as a function of nitrogen intake and described by a series of curves using a four-parameter logistic model. Parame...

Journal: :IEICE Transactions 2007
Yafei Hou Masanori Hamamura

SUMMARY In this paper, we propose a new modulation named parallel combinatory/high compaction multi-carrier modulation (PC/HC-MCM) using the techniques of parallel combinatory orthogonal frequency division multiplexing (PC-OFDM) and high compaction multi-carrier modulation (HC-MCM). Two types of PC/HC-MCM systems, which are named as modulated PC/HC-MCM system and (unmodulated) PC/HC-MCM system ...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2001
M V Meng G D Grossfeld G H Williams S Dilworth K Stoeber T W Mulley V Weinberg P R Carroll T D Tlsty

The minichromosome maintenance (MCM) proteins are highly conserved proteins essential for initiating and regulating eukaryotic DNA replication. Recent studies have demonstrated the potential use of MCM proteins as markers of proliferation. We characterized the pattern of Mcm 2 staining in benign and malignant prostate tissues and examined the role of Mcm 2 expression in disease-free survival af...

Journal: :Molecular biology of the cell 1999
S G Pasion S L Forsburg

The minichromosome maintenance (MCM) proteins MCM2-MCM7 are conserved eukaryotic replication factors that assemble in a heterohexameric complex. In fission yeast, these proteins are nuclear throughout the cell cycle. In studying the mechanism that regulates assembly of the MCM complex, we analyzed the cis and trans elements required for nuclear localization of a single subunit, Mcm2p. Mutation ...

Journal: :Nanomaterials and Nanotechnology 2023

Ecofriendly chitosan/Al-MCM-48 (CH/Al-MCM) was synthesized from natural microcline and assessed as a potential adsorbent of As (V) ions with enhanced capacity. The adsorption properties CH/Al-MCM were in comparison Al-MCM-41 single phase. studied exhibits 178.6 mg/g capacity which is higher than (124 mg/g). illustrated based on the pseudo-first-order kinetic, Langmuir isotherm, monolayer model ...

Journal: :Biochimica et biophysica acta 1998
S E Kearsey K Labib

5. Regulation of MCM proteins during the cell cycle . . . . . . . . . . . . . . . . . . . . . . . . . . . . 125 5.1. MCM protein levels in proliferating and non-proliferating cells . . . . . . . . . . . . . . . . . 125 5.2. Involvement of ORC and Cdc6rcdc18 in binding of MCM proteins to chromatin . . . . . . 126 5.3. Role of phosphorylation in regulating MCM function . . . . . . . . . . . . . ....

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