Objective: Extracts of Anchomanes difformis (AD) are used in folkloric medicine to treat several diseases and infections. However, their roles in mitochondrial permeability transition pore opening are not known. Material and Methods: The viability of mitochondria isolated from Wistar rat liver used in this experiment, was assessed by monitoring their swel...

The extract of Angelicae dahuricae radix has traditionally been used as an anti-noceptive remedy in China. In this study, the methanol extract of Angelicae dahuricae radix (MEAD) was evaluated to determine if it has anti-noceptive and anti-inflammatory action. The anti-nociceptive activities of MEAD were evaluated by determining the writhing response and sleeping time, as well as by a formalin ...

Mead is perhaps the oldest fermented drink in the world, yet it is difficult to find it commercially. A brief review of the history of mead, its value as a health tonic and technology of mead production has been given in the present paper. Fermentation of honey can be used to produce different varieties of mead, sherry, sparkling wine and fruit-honey wines and it may have different flavours dep...

In this paper, we first prove that the expansion and contraction steps of the Nelder-Mead simplex algorithm possess a descent property when the objective function is uniformly convex. This property provides some new insights on why the standard Nelder-Mead algorithm becomes inefficient in high dimensions. We then propose an implementation of the Nelder-Mead method in which the expansion, contra...

Introduction An early textbook in hydrology (Mead 1919) contains a remarkable chapter on ground water as well as two chapters on geology. The author, Daniel W. Mead, a professor of hydraulic and sanitary engineering at the University of Wisconsin (now the University of WisconsinMadison), based the text on lecture notes (published earlier, Mead [1904]) for his course in general hydrology. In fac...

The Nelder–Mead simplex algorithm, first published in 1965, is an enormously popular direct search method for multidimensional unconstrained minimization. Despite its widespread use, essentially no theoretical results have been proved explicitly for the Nelder–Mead algorithm. This paper presents convergence properties of the Nelder–Mead algorithm applied to strictly convex functions in dimensio...

Honey is a natural product with recognized physical and chemical properties, which contribute to its biological activity. However, honey is currently being sold at low prices, making it imperative to find alternatives to make apiculture a viable national enterprise. One of these alternatives could be mead production. Despite the excellent properties of honey, mead production faces several probl...