Background and Objective: The primary goal of this study is to develop a rigorous understanding ofthe correlation between COX-2 expression and malignant melanoma prognostic factors. Material and Methods: In this cross-sectional study, we analyzed 60 cases of cutaneous malignant melanoma. The related stained slides were reviewed by two pathologists. The re...

introduction in order to treat uveal melanoma , first, radioactive seeds are laid on a silicone- made substance which is called silastic after that they are inserted in the plaque, and finally, this plaque containing silicone-made substance is stitched to the sclera surface. the dose gradient within the tumor and healthy tissues can be varied due to changing the silastic thickness between scler...

background: melanoma progression and metastasis is suggested to be mediated by increased accumulation of myeloid derived suppressor cells. various chemotherapeutic drugs such as 5-fluorouracil in single low concentration have the capacity, at least in part, to reverse tumor progression by reducing myeloid derived suppressor cellsmediated immunosuppression. objective: to assess whether multiple ...

cytokines influence cell cycle events, which in some but not all instances can be associated with melanoma progression. analysis of the g0/g 1 and s phase fractions of the cell cycle was used to assay the proliferative or inhibitory activity of cytokines against ten human melanoma cell lines, including pairs of cell lines derived from primary and metastatic tissue of individual patients. cytoki...

Background: Skin cancer is one of the most common forms of cancer in the world and melanoma is the deadliest type of skin cancer. Both melanoma and melanocytic nevi begin in melanocytes (cells that produce melanin). However, melanocytic nevi are benign whereas melanoma is malignant. This work proposes a deep learning model for classification of these two lesions.    Methods: In this analytic s...

introduction: the incidence of malignant melanoma is increasing at a rate greater than any other human cancer. although melanoma accounts for only 4 percent of all dermatologic cancers, it is responsible for 80 percent of deaths from skin cancer; only 14 percent of patients with metastatic melanoma survive for five years. the optimal therapy varies with the stage of the disease. surgical excisi...

two new potential magnetic resonance imaging contrast agents, gd-hematoporphyrin (gd-h) and gd-tetra-carboranylmethoxyphenyl-porphyrin (gd tcp), were synthesized and applied to nude mice with human melanoma (mm 138) xenografts. these agents showed a high relaxivity because of their greater potential to coordinate water molecules. the reduction of t1 relaxation times of 16 and 21% was observed i...