objective(s): many cancer cells show significant resistance to drugs that kill drug sensitive cancer cells and non-tumor cells and such resistance might be a consequence of the difference in metabolism. therefore, studying the metabolism of drug resistant cancer cells and comparison with drug sensitive and normal cell lines is the objective of this research. material and methods:metabolism of c...

background: the aim of the study was to research concerning the epidemiology of newborns' galactosemia during 2007-2008 to find out whether screening was necessary for iranian newborns or not and also what the symptoms of this disease before or after diet were. methods: the data were collected from 24000 newborn babies from fars province, southern iran. the enzymatic calori­metric test was done...

bone is formed through the processes of endochondral and intramembranous ossification. in endochondral ossification primary mesenchymal cells differentiate to chondrocytes and then are progressively substituted by bone, while in intramembranous ossification mesenchymal stem cells (mscs) differentiate directly into osteoblasts to form bone. the steps of osteogenic proliferation, differentiation,...

background and aims: medicinal plants are a valuable resource for flavonoids extraction. prosopis fracta is one of the plants with medicinal properties. prosopis fracta was found in abundance in southern regions in iran. coersetin is medicinal substance found in the fruit of this plant. quercetin is used in treatment of cancer and viral infections. this study was conducted to determine the quer...

context:micrornas (mirnas) are a class of short, endogenously-initiated, non-coding rnas that post-transcriptionally control gene expression via translational repression or mrna turnover. mirnas have attracted much attention in recent years as they play critical roles in gene expression and are promising tools with many biotech and therapeutic applications. the molecular mechanisms underlying t...

animal agricultural production systems are major sources of nonpoint pollution affecting quality of water sources. nitrogen has been identified as the foremost source of nonpoint water pollution  and the potential negative impacts of n have become an area of public concern. protein degradation from feed ingredients is an important factorinfluencing aa supply to the duodenum. ruminal proteolysis...

fasting induces short-term physiological adaptations which spare the body's remaining carbohydrate stores and mobilize lipid stores to provide a substitute fuel for many tissues and organs, especially skeletal muscle. rodent studies show that regular occurrence of fasting then refeeding, stimulates adaptations in muscle which make the animal better placed to withstand a further period of fastin...

conclusions according to the results of the present study, aerobic exercise at moderate intensity and proper time can be considered as a special treatment to prevent diabetes complications and related disorders, particularly obesity. objectives this study aimed to determine whether in patients with type 2 diabetes, substrate oxidation and energy expenditure were affected by the type of intensit...