asthma affects an estimated 300 million people worldwide. poor compliance with the prescribed medication leads to increased mortality and morbidity. various determinants of compliance have been described. the purpose of this study was to determine factors that can influence patients' compliance with prescribed metered dose inhaler drugs. 179 patients with diagnosis of asthma were selected from ...

OBJECTIVE To determine the clinical effectiveness of pressurised metered dose inhalers (with or without spacer) compared with other hand held inhaler devices for the delivery of corticosteroids in stable asthma. DESIGN Systematic review of randomised controlled trials. DATA SOURCES Cochrane Airways Group trials database (Medline, Embase, Cochrane controlled clinical trials register, and han...

BACKGROUND The metered dose inhaler is difficult to use correctly, synchronising actuation with inhalation being the most important problem. A breath actuated pressurised inhaler, designed to help patients with poor inhaler technique, was compared with a conventional metered dose inhaler in terms of aerosol deposition and bronchodilator response. METHODS Radioaerosol deposition and bronchodilat...

AIMS To see if elderly people can use the breath-activated (Easi-breathe) and dry powder (Turbohaler) inhalers as effectively as the metered-dose inhaler and Volumatic system. METHODS 102 inhaler-naive patients (aged 75-101, mean 84 years), without cognitive impairment, were randomly allocated one of Easi-breathe, Turbohaler or metered-dose inhaler and Volumatic placebo inhalers. Standardized...

The lung dose and deposition patterns of drug delivered by dry powder inhaler are not known. The effects of inhaling 400 micrograms salbutamol delivered by dry powder inhaler (two 200 micrograms salbutamol Rotacaps), by pressurised metered dose inhaler, and by Acorn nebuliser were studied in nine subjects with chronic stable asthma. Technetium-99m labelled Teflon particles were mixed with micro...

PRODUCT DESCRIPTION Salmeterol + Fluticasone propionate (Seretide) 25/50mcg Metered Dose Inhaler: Each single actuation provides salmeterol xinafoate equivalent to 25mcg of salmeterol and 50mcg of fluticasone propionate. Salmeterol + Fluticasone propionate (Seretide) 25/125mcg Metered Dose Inhaler: Each single actuation provides salmeterol xinafoate equivalent to 25mcg of salmeterol and 125mcg ...

A radiotracer technique has been used to assess aerosol delivery from a pressurised metered dose inhaler, used both with and without a 10 cm cylindrical spacer attachment (Syncroner), which has an open section in its upper surface. The radionuclide technetium-99m (99mTc) was added to sodium cromoglycate in a canister (Intal inhaler; 1 mg/puff); in vitro studies with a multistage liquid impinger...

Several readers wrote to us to express their concern about the image the BMJ chose to accompany this Analysis article by Ingrid Wolfe and colleagues (BMJ 2011;342:d1277, doi:10. 1136/bmj.d1277) in the print issue of 23 April (page 903). It showed a metered dose inhaler being administered to an infant without use of a spacer. According to the British Guideline on the Management of Asthma, for ch...

responses to salbutamol using Diskhaler versus metered-dose inhaler. Comparison of the bronchodilating efficacies of a novel salbutamol metered dose powder inhaler and a pressurised metered dose aerosol with a spacer. Efficacy of a new non-ozone depleting formulation for salbutamol. Comparison of inhaled ter-butaline administered by either the Turbuhaler dry powder or a metered-dose inhaler wit...