this study was designed to explore the protective effects of ascorbic acid and water extract of spirulina platensis (blue green algae) on methotrexate-induced lipid peroxidation using goat liver as the lipid source. this in vitro evaluation was done by measuring the malondialdehyde, 4-hydroxy-2-nonenal, reduced glutathione and nitric oxide content of tissue homogenates. the study reveals the li...

Introduction: Methotrexate as a single agent chemotherapy in most women with low risk gestational trophoblastic neoplasia (GTN) has been associated with high treatment rate. Combination of methotrexate with Vitamin A due to reduced number of chemotherapy regime courses is one of the treatment options for patients with low-risk GTN. Therefore, this study was performed with aim to determine the e...

background: cervical pregnancy is rare and dangerous form of ectopic pregnancy which can be treated surgically or conservatively. methotrexate is reasonable conservative option with high efficiency and acceptable level of side effects. aim of this paper is to present possible treatment option in case of methotrexate failure, still keeping the postulates of minimal invasive surgery. case:  we de...

background methotrexate is a folic acid antagonist that has been in clinical use for five decades. its use in patients with brain tumors is primarily confined to primary central nervous system lymphoma (pcnsl), in which it is the cornerstone of chemotherapy. objectives a selective and sensitive high-performance liquid chromatography-electrospray ionization-mass spectrometry method was developed...

objective: to evaluate the plasma creatine phosphokinase (cpk) level after a single injection of methotrexate (mtx) as a predictor of treatment success in ectopic pregnancy (ep). materials and methods: in this prospective study, seventy nine women older than 18 years treated with methotrexate for ectopic pregnancy were evaluated for cpk and β-subunit of human chorionic gonadotropin (βhcg) level...

A study was undertaken to evaluate the Nucleolar organizing regions (NOR) count and histopathological changes in rat’s liver treated with methotrexate (MTX). Male Wistar rats aged 4 months, maintained in our institution were used in the present study. Animals were injected intraperitonealy with 3 different doses of methotrexate on alternative days for one week and the animals were sacrifi...

Methotrexate reduces intracellular pools of 5-methyltetrahydrofolate and could result in reduced conversion of homocysteine to methionine by methionine synthetase. This study was designed to investigate the effects of moderate dose to very high dose methotrexate on methionine and total homocysteine as reflections of methotrexate induced intracellular events. Methionine and total homocysteine we...

objective: to evaluate the plasma creatine phosphokinase (cpk) level after injection of methotrexate (mtx) as a predictor of treatment success in ectopic pregnancy (ep). materials and methods: one hundred women treated with single dose of methotrexate for ectopic pregnancy were evaluated in a prospective study, for cpk and ß-subunit of human chorionic gonadotropin (ß-hcg) levels. they received ...