Methoxylated flavones were recently shown to be promising cancer chemopreventive agents. Their high metabolic stability compared with the hydroxylated analogs was shown in our laboratory using the human hepatic S9 fraction with cofactors for glucuronidation, sulfation, and oxidation. In the present study, the resistance of methoxylated flavones toward oxidative metabolism was investigated with ...

The structure-activity relationships between flavonoids and their tracheal relaxant action are little known. In the present study, 26 natural and synthetic flavonoids, divided into the five classes of flavones, flavonols, flavanones, isoflavones, and chalcones, were tested, and their IC (50) values were determined. The IC (50) values of these five classes indicated that flavones were more poten...

aerial parts of salvia mirzayanii was extracted with methanol. methanol extract was suspended in water and defatted with petroleum ether. the defatted part was then partitioned between ethyl acetate and water. the ethyl acetate partition was chromatographed on a silica gel column to afford several fractions. lymphocyte proliferation inhibitory assay of the resulted fractions was compared in vit...

Methoxylated flavones were recently shown to be promising cancer chemopreventive agents. Their high metabolic stability compared with the hydroxylated analogs was shown in our laboratory using the human hepatic S9 fraction with cofactors for glucuronidation, sulfation, and oxidation. In the present study, the resistance of methoxylated flavones toward oxidative metabolism was investigated with ...

Methoxylated flavones were recently shown to be promising cancer chemopreventive agents. Their high metabolic stability compared with the hydroxylated analogs was shown in our laboratory using the human hepatic S9 fraction with cofactors for glucuronidation, sulfation, and oxidation. In the present study, the resistance of methoxylated flavones toward oxidative metabolism was investigated with ...

Chemical studies of Praxelis clematidea R.M. King & Robinson resulted in the isolation of six flavones: Apigenine, genkwanine, 7,4'-dimethylapigenin, trimethylapigenin, cirsimaritin and tetramethylscutellarein, which were tested for their toxicity against Staphylococcus aureus SA-1199B, a strain possessing the NorA efflux pump. Efflux pumps are integral proteins of the bacterial membrane and ar...

Galium species are used as diuretics, choleretics, against diarrhea and in the treatment of some stomach complaints, gout and epilepsy in folk medicine. Most of these species have been extensively investigated for antraquinones and iridoids but little is known about other bioactive compounds classes. Our research aimed to investigate the chemical composition of four Romanian species of Galium i...

the genus thymus l. belongs to the lamiaceae family, consist of about 215 species of herbaceous perennials and small shrubs in the world. they originated from mediterranean region. this genus is presented in iranian flora by 14 species, including: t. daenensis, t. carmanicus, t. fallax, t. persicus, t. trautvetteri, t. migricus, t. kotschyanus, t. pubesens, t. nummularius, t. transcaspicus, t. ...