This paper presents MASCOT (MicroArchitecture Synthesis of ConTrol paths). This synthesis system constructs the optimal microarchitecture for a control path of an instruction set processor. Input to the system is the behavioural specification of a control path. This specification is in finite state machine form which is mapped initially onto a single programmed logic array (PLA) microarchitectu...

Introducing a New Dynamically and Design-Scalable Microarchitecture that Rewrites the Book on Energy Efficiency and Performance Since the introduction of Intel® CoreTM microarchitecture in 2006 and its 2007 45nm enhancements—the Intel Core microarchitecture (Penryn) family of processors—the blistering performance and energy efficiency of Intel® microprocessors have delivered unprecedented capab...

background: appropriate endurance exercise can change bone mass density and strength of weight-bearing bones in both animals and humans, but its effects on the microstructure are not known. this study aimed to determine skeletal changes induced by the treadmill running endurance in ovariectomized adult mice. methods: twenty-seven adult female rats were divided into experimental and control grou...

BACKGROUND Bone microarchitecture is a significant determinant of bone strength. So far, the assessment of bone microarchitecture has required bone biopsies, limiting its utilization in clinical practice to one single skeletal site. With the advance of high-resolution imaging techniques, non-invasive in vivo measurement of bone microarchitecture has recently become possible. This provides an op...

UNLABELLED It has been suggested that age-related deterioration in trabecular microarchitecture and changes in collagen cross-link concentrations may contribute to skeletal fragility. To further explore this hypothesis, we determined the relationships among trabecular bone volume fraction (BV/TV), microarchitecture, collagen cross-link content, and bone turnover in human vertebral trabecular bo...

Developing a novel technique for the efficient, noninvasive clinical evaluation of bone microarchitecture remains both crucial and challenging. The trabecular bone score (TBS) is a new gray-level texture measurement that is applicable to dual-energy X-ray absorptiometry (DXA) images. Significant correlations between TBS and standard 3-dimensional (3D) parameters of bone microarchitecture have b...

We propose a methodology for validating microarchitecture speciications. We view microarchitecture features as speciic operations on entries of various buuers in the processor. Our validation approach is to determine the functionality of a buuer type, model its operations at the microarchitecture level using abstract nite state machine (FSM) models, and rigorously generate instruction sequences...

We demonstrate the repeatability of lamina cribrosa (LC) microarchitecture for in vivo 3D optical coherence tomography (OCT) scans of healthy, glaucoma suspects, and glaucomatous eyes. Eyes underwent two scans using a prototype adaptive optics spectral domain OCT (AO-SDOCT) device from which LC microarchitecture was semi-automatically segmented. LC segmentations were used to quantify pore and b...