objective(s):degradation of sphingosine 1-phosphate (s1p), as a bioactive lipid, or deregulation of its production involves in tumor progression, metastasis and chemoresistance. since the tumor progression effects of s1p and its mechanism in chronic lymphoblastic leukemia and non-small cell lung cancer is not fully understood, we investigated the role and one of the mechanisms of s1p in tumor p...

Objective(s): In order to grow cells in a three-dimensional (3D) microenvironment, self-assembling peptides, such as PuraMatrix, have emerged with potential to mimic the extracellular matrix. The aim of the present study was to investigate the influence of the self-assembling peptide on the morphology, survival, proliferation rate, migration potential, and differentiation of human meningioma st...

Background: The MET receptor is a critical member of cancer-associated RTKs and plays an important role in different biological activities, including differentiation, migration, and cell proliferation. Methods: In this study, novel MET inhibitors were introduced and applied on esophageal squamous carcinoma cell line KYSE-30, and the level of proliferation and migration, as well as the activated...

The forebrain comprises an intricate set of structures that are required for some of the most complex and evolved functions of the mammalian brain. As a reflection of its complexity, cell migration in the forebrain is extremely elaborated, with widespread dispersion of cells across multiple functionally distinct areas. Two general modes of migration are distinguished in the forebrain: radial mi...

objective(s):breast cancer is an important leading cause of death from cancer. stathmin and tau proteins are regulators of cell motility, and their overexpression is associated with the progression and bad prognosis of breast cancer. memantine, an n-methyl-d-aspartate (nmda) receptor antagonist, is the potential inhibitor of tau protein in neurons. this study determines the effect of memantine ...

this study is a descriptive - survey and objective evaluation analysis of creation causes on informal settlement shadgholi-khan town of qom city. answer questionnaire by 200 protector of household in shadgholi-khan tow, economic, social and physical variables affective creation of informal settlements in the shadgholi-khan its spatial and local effects are investigated. research findings show t...

the purpose of this descriptive correlational study was to investigate the tendency level of youth in rural areas of kermanshah township to migration, and to determine the influencing factors. the statistical population for the study was constituted of the rural boys (15-28 years) of kermanshah township (n= 17544). a multistage sample of rural youth was selected (n=291). the findings indicated ...

Ventriculoperitoneal (VP) shunt is one of the most common pediatric neurosurgical procedures. It has various complications that may have serious consequences such as shunt dysfunction, and unusual migration. Although, migration of shunt catheter to bladder, heart, umbilicus, rectum, pulmonary artery, and stomach has been reported, migration to vagina is a rare one.In this report we present a 16...

Spatial mobility is a topical concept of analytical migration science, which makes it possible to assess the desires, readiness and capabilities of the population to move over certain distances and time. In the management of spatial mobility assessment requires the organization of systematic monitoring, which includes identifying the mobility potential in spatial and temporal interpretation, th...