We introduce aligned hierarchies, a low-dimensional representation for music-based data streams, such as recordings of songs or digitized representations of scores. The aligned hierarchies encode all hierarchical decompositions of repeated elements from a high-dimensional and noisy music-based data stream into one object. These aligned hierarchies can be embedded into a classification space wit...

Abstract Background MicroRNAs (miRNAs, miR) are essential gene expression regulators involved in numerous biological processes and diseases including type 2 diabetes (DM). Purpose We aimed to determine the predictive value of selected circulating miRNAs for cardiovascular all-cause mortality their potential usefulness as biomarkers DM patients. Method Two hundred fifty-two patients with were en...

Systems for the archival of musical documents digitally and development of digital music libraries are currently being researched and developed extensively. However, adapting these systems for the archival and retrieval of Malaysian music materials might not be as straightforward due to the distinct differences in musical structure and modes of non-Western music. This paper covers the motivatio...

Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA; Computation and Systems Biology, Singapore-Massachusetts Institute of Technology Alliance, Singapore 117576; Stem Cell and Developmental Biology, Genome Institute of Singapore, A*STAR, Singapore 138627; Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA; Department of Bi...

MicroRNAs (miRNAs) have recently taken center stage in the field of human molecular oncology. Most of the chemotherapeutics are able to interfere with nucleic acid metabolism and gene expression. The purpose of this study was to determine how 5-fluorouracil (5-FU) and oxaliplatin (L-OHP) modify the expression profiles of miRNAs in HCT-8 and HCT-116 colon cancer cells and whether the pharmacodyn...

BACKGROUND To examine human microRNA expression in fertile men and subsequently to compare expression patterns of miRNAs in fertile and infertile men, specifically men with Sertoli Cell Only (SCO) histopathology. METHODS Testicular tissues from men with azoospermia and SCO, as well as those of men with normal spermatogenesis, were analyzed. MicroRNA was isolated using the miRCURY™ RNA Purific...