نتایج جستجو برای: mir33
تعداد نتایج: 18 فیلتر نتایج به سال:
MicroRnAs (miRnAs) are non-coding RnAs that downregulate gene expression at the post-transcriptional level. in recent years, their regulatory roles have been receiving much attention. MiR33 is one such miRnA, recently identified as a critical regulator of cholesterol homeostasis1 and insulin signaling.2 The recent study by Cirera-salinas et al.3 described a new role of miR33 for the regulation ...
RATIONALE Diabetes mellitus increases cardiovascular disease risk in humans and remains elevated despite cholesterol-lowering therapy with statins. Consistent with this, in mouse models, diabetes mellitus impairs atherosclerosis plaque regression after aggressive cholesterol lowering. MicroRNA 33 (miR33) is a key negative regulator of the reverse cholesterol transport factors, ATP-binding casse...
OBJECTIVE miR-33 has emerged as an important regulator of lipid homeostasis. Inhibition of miR-33 has been demonstrated as protective against atherosclerosis; however, recent studies in mice suggest that miR-33 inhibition may have adverse effects on lipid and insulin metabolism. Given the therapeutic interest in miR-33 inhibitors for treating atherosclerosis, we sought to test whether pharmacol...
Plasma HDL levels have a protective role in atherosclerosis, yet clinical therapies to raise HDL levels have remained elusive. Recent advances in the understanding of lipid metabolism have revealed that miR-33, an intronic microRNA located within the SREBF2 gene, suppresses expression of the cholesterol transporter ABC transporter A1 (ABCA1) and lowers HDL levels. Conversely, mechanisms that in...
RATIONALE Therapeutically targeting macrophage reverse cholesterol transport is a promising approach to treat atherosclerosis. Macrophage energy metabolism can significantly influence macrophage phenotype, but how this is controlled in foam cells is not known. Bioinformatic pathway analysis predicts that miR-33 represses a cluster of genes controlling cellular energy metabolism that may be impo...
MicroRNAs (miRNAs) are a specialized group of small RNAs (sRNAs) that regulate gene expression in plants at both transcriptional and post-transcriptional levels. Numerous families miRNA target genes involved regulating plant immunity. In this study, we studied the role miRNAs defensive response against fungal pathogen, Fusarium oxysporum f. sp. lycopersici, which causes wilt disease tomatoes. F...
bachgroun: hematopoietic stem cell derived from umbilical cord blood (ucb) has been used for regenerative medicine in hematological abnormalities. micrornas are important regulators of gene expression that control both physiological and pathological processes such as development of tissue and cancer. some studies have shown that mir-33, has a critical role in control of self-renewal cells. here...
1 identify a novel regulatory loop of hepatic cholesterol bio-synthesis and export in mice involving the nuclear bile acid receptor FXR/NR1H4. Through transcriptional regulation of the Srebf2 gene and its intronic microRNA mmu-miR33, FXR is now shown to participate in cholesterol homeostasis by post-transcriptional silencing of mir33 targets, including Abca1, a major determinant of hepatic high...
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