In order to evaluate internal dose, MIRD system was proposed by Society of Nuclear Medicine in 1976. MIRDOSE3 computer software based on this concept is currently the most frequently used tool to calculate the organ dose in nuclear medicine community. Unfortunately it uses fixed anthropomorphic phantoms, so the geometric parameters of organs are short of individual characteristics. Although the...

UNLABELLED The contribution to red marrow absorbed dose from beta-emitting radionuclides distributed uniformly in the total body can be overestimated using either MIRD 11 or MIRDOSE3. The S value assigned to the red marrow target region from activity distributed in the remainder of the body is of particular concern. The assumption that the specific absorbed fraction for total body irradiating r...

Dosimetry for targeted radionuclide therapy is a relatively young field. Although initial work can be traced back to the late 1940s (1), the MIRD Committee formalism that forms the foundation for most current approaches was published in the mid 1970s (2), and the drive for improved dosimetry to meet the requirements of targeted radionuclide therapy did not begin until the 1980s. During this per...

background: radiation absorbed dose to the red bone marrow, a critical organ in the therapy of thyroid carcinoma, is generally kept below 2 gy for non-myeloablative therapies. the aim of this study was to calculate bone marrow radiation dose by using mirdose3 package program and to optimize the safe limit of activity to be administered to the thyroid cancer patients. materials and methods: in t...

UNLABELLED 18F-labeled 2 beta-carbomethoxy-3beta-(4-chlorophenyl)-8-(-2-fluoroethyl)nortropane ([18F]FECNT) is a recently developed dopamine transporter ligand with potential applications in patients with Parkinson's disease and cocaine addiction. METHODS Estimates of the effective dose equivalent and doses for specific organs were made using biodistribution data from 16 Sprague-Dawley rats a...

BACKGROUND: A study for pain relief therapy with 188Re-HEDP was done in patients with bone metastases secondary to breast and prostate cancer. MATERIALS AND METHODS: Patients received 1.3 or 2.2 GBq, in single or multiple doses. Platelets, white and red cells were evaluated during 11 weeks. Pharmacokinetic characterization was done from blood and urine samples for 5 patients along 24 hours. Uri...

Our previous dosimetry studies have demonstrated that for dopaminergic radiotracers, (18)F-FDOPA and (18)F-FPCIT, the urinary bladder is the critical organ. As these tracers accumulate in the basal ganglia (BG) with high affinity and long residence times, radiation dose to the BG may become significant, especially in normal control subjects. We have performed dynamic PET measurements using (18)...

Background: Radia on absorbed dose to the red bone marrow, a cri cal organ in the therapy of thyroid carcinoma, is generally kept below 2 Gy for non-myeloabla ve therapies. The aim of this study was to calculate bone marrow radia on dose by using MIRDOSE3 package program and to op mize the safe limit of ac vity to be administered to the thyroid cancer pa ents. Materials and Methods: In this stu...

UNLABELLED The present study estimated the biodistribution and radiation-absorbed dose of epidermal growth factor receptor (EGFR) radioligand 11C-PD153035 in whole-body PET examinations of healthy volunteers. METHODS Two-dimensional whole-body PET was performed on 9 subjects after injection of 11C-PD153035 at 329.3+/-77.8 MBq (mean+/-SD). A total of 12 frames were acquired for approximately 9...

Background: Radiation absorbed dose to the red bone marrow, a critical organ in the therapy of thyroid carcinoma, is generally kept below 2 Gy for non-myeloablative therapies. The aim of this study was to calculate bone marrow radiation dose by using MIRDOSE3 package program and to optimize the safe limit of activity to be administered to the thyroid cancer patients. Materials and Methods: In t...