نتایج جستجو برای: mitochondria

تعداد نتایج: 46868  

Journal: :medical journal of islamic republic of iran 0
a. majid cheraghali from the department of pharmacology and toxicology, faculty of medicine, baghyatollah university of medical sciences, tehran, i.r. iran alan r.p paterson the department of pharmacology, university of alberta, edmonton, alberta, canada. wendy p. gati the department of pharmacology, university of alberta, edmonton, alberta, canada.

in this study the uptake and metabolism of adenosine by mitochondria has been investigated. incubation of cem cells mitochondria preparation with [3h] -adenosine showed substantial uptake and metabolism of adenosine. adenosine was both anabolized to amp, adp and atp, and also catabolized to inosine. the highest concentration of metabolites in extracted mitochondria was due to amp. the mitochond...

A. MAJID CHERAGHALI, ALAN R.P PATERSON, WENDY P. GATI,

In this study the uptake and metabolism of adenosine by mitochondria has been investigated. Incubation of CEM cells mitochondria preparation with [3H] -adenosine showed substantial uptake and metabolism of adenosine. Adenosine was both anabolized to AMP, ADP and ATP, and also catabolized to inosine. The highest concentration of metabolites in extracted mitochondria was due to AMP. The mito...

Journal: :the iranian journal of pharmaceutical research 0
jalal pourahmad department of pharmacology and toxicology, school of pharmacy, shahid beheshti university of medical sciences tehran, iran. mir jamal hosseini department of pharmacology and toxicology, school of pharmacy zanjan university of medical sciences zanjan, iran.

mitochondria are unique organelles with major role in cellular function, not only as a major site of atp production, but also by regulating energy expenditure, apoptosis signaling, and production of reactive oxygen species. they play a central role in determining the point-of-no-return for the apoptotic process. there is accumulating evidence supporting a direct link between mitochondria, oxida...

Journal: :iranian journal of pharmaceutical research 0
abbas rezaeian mehrabadi department of pharmacology and toxicology, faculty of pharmacy, shiraz university of medical sciences, shiraz, iran akram jamshidzadeh pharmaceutical sciences research center, and department of pharmacology and toxicology, faculty of pharmacy, shiraz university of medical sciences, shiraz, iran marzieh rashedinia department of pharmacology and toxicology, faculty of pharmacy, shiraz university of medical sciences, shiraz, iran hossein niknahad pharmaceutical sciences research center, and department of pharmacology and toxicology, faculty of pharmacy, shiraz university of medical sciences, shiraz, iran

pioglitazone (pg) is one of thiazolidinediones used for the treatment of type ii diabetes mellitus. some reports of its hepatotoxicity exist, but the mechanism of its hepatotoxicity is not well known. in the present study, the protective effect of some atp suppliers are investigated against mitochondrial toxicity of pg in isolated rat mitochondria. mitochondrial viability was investigated by mt...

Journal: :iranian biomedical journal 0
محمد حسین صالحی mohammad hossein salehi مسعود هوشمند massoud houshmand امید آریانی omid aryani بهنام کمالی دهقان behnam kamalidehghan الهام خلیلی elham khalili

background: friedreich ataxia (frda) is an autosomal recessive disorder caused by guanine-adenine-adenine (gaa) triplet expansions in the fxn gene. its product, frataxin, which severely reduces in frda patients, leads to oxidative damage in mitochondria. the purpose of this study was to evaluate the triple nucleotide repeated expansions in iranian frda patients and to elucidate distinguishable ...

Journal: :iranian biomedical journal 0
محبوبه عموشاهی mahboobeh amoushahi مژده صالح نیا mojdeh salehnia سامان حسین خانی saman hosseinkhani

background: the mitochondria are an important source of adenosine triphosphate (atp) production in pre-implantation embryo. therefore, the objective of this study was to investigate the effect of vitrification and in vitro culture of mouse embryos on their mitochondrial distribution and atp content. methods: the embryos at 2-pn, 4-cell and blastocyst stages were collected from the oviduct of st...

Journal: :iranian journal of child neurology 0
mahmoud reza ashrafi 1. pediatric neurology department, children’s medical center, pediatric center of excellence, tehran university of medical science, tehran, iran alireza tavasoli 1. pediatric neurology department, children’s medical center, pediatric center of excellence, tehran university of medical science, tehran, iran

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Previous studies demonstrated that CSE induces oxidative stress and its consequences on isolated mitochondria obtained from lung, heart and brain which may provide insight into the role of CSE in human health and disease. The present study was carried out to further characterize and compare toxic effect of CSE extract on isolated mitochondria obtained from either a directly contacting tissue (i...

Natural products isolated from plant sources are well known for their pharmacological potential in diversity of disease treatments such as inflammatory or cancer conditions. Mango (Mangifera indica L.) and Juglans regia are thought to be rich of functional phytochemicals. To elucidate the anticancer activity of Juglans regia (JR) and Mangifera indica L (MI) aqueous extract were investigated on ...

Natural products isolated from plant sources are well known for their pharmacological potential in diversity of disease treatments such as inflammatory or cancer conditions. Mango (Mangifera indica L.) and Juglans regia are thought to be rich of functional phytochemicals. To elucidate the anticancer activity of Juglans regia (JR) and Mangifera indica L (MI) aqueous extract were investigated on ...

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