Mục tiêu: Sử dụng kính hiển vi điện tử truyền qua (TEM) để xem xét siêu cấu trúc gan của các bệnh nhân phơi nhiễm dioxin mạn tính. Đối tượng và phương pháp: Nghiên cứu sử mẫu sinh thiết 33 bị ở Việt Nam, loại trừ có ung thư hoặc virus viêm gan. Phương pháp nghiên mô tả cắt ngang, với việc TEM thực hiện phân tích nhân. Kết quả: quả cho thấy tổn thương đồng nhất tế bào nhu gan, đặc biệt là trong ...

The energy demand of cardiomyocytes changes continuously in response to variations cardiac workload. Cardiac excitation-contraction coupling is fueled primarily by adenosine triphosphate (ATP) production oxidative phosphorylation mitochondria. rate mitochondrial metabolism matched the ATP consumption cytosol parallel activation calcium (Ca 2+ ) and diphosphate (ADP). During workload transitions...

Abstract Background Nbp35-like proteins (Nbp35, Cfd1, HCF101, Ind1, and AbpC) are P-loop NTPases that serve as components of iron-sulfur cluster (FeS) assembly machineries. In eukaryotes, Ind1 is present in mitochondria, its function associated with the FeS clusters subunits respiratory Complex I, Nbp35 Cfd1 cytosolic (CIA) pathway, HCF101 involved photosystem I plastids plants (chHCF101). The ...

Sickle cell disease (SCD) is characterised by chronic haemolysis and oxidative stress. Herein, we investigated 30 SCD patients found 40% with elevated mitochondria levels (SS-mito+ ) in their mature red blood cells, while 60% exhibit similar compared to the AA group (SS-mito- ). The SS-mito+ are higher reticulocytosis total bilirubin levels, lower foetal haemoglobin, non-functional mitochondria...

We demonstrated nanoscale MRI of metabolism in single isolated mitochondria and within living cells using NV centers diamond.

purpose : to investigate the effects of mtp-131 on trabeculum cells cultured under hydrostatic pressure methods : glaucomatous human trabecular meshwork (gtm3) cells were divided into three groups: the mtp-131 group, the hydrostatic group, and the normal group. the mtp-131 group was pretreated with 1 µm mtp-131, and the cells were then cultured under 80 mmhg pressure for 24 hours. the normal gr...

objective: mitochondria is a critical organelle within the cell and has important role in the oocyte development, thus the aim of this study was the comparison of mitochondrial distribution within the mouse oocyte at germinal vesicle (gv), germinal vesicle breakdown (gvbd) and metaphase ii (mii) stages using laser confocal microscopy (lscm). materials and methods: after superovulation of adult...

ABSTRACT Mitochondria provide cellular energy through oxidative phosphorylation, and thus temperature-induced constraints on mitochondrial function may be crucial to animal aerobic scope thermal tolerance. Here, we report the effect of temperature in range 5–30°C respiration rates isolated cardiac mitochondria from rainbow trout (Oncorhynchus mykiss) studied by high-resolution respirometry spec...

Cutting to the Core, a book on surgical ethics, begins by quoting a portion of the Hip-pocratic oath: to " first, do no harm. " It is a fitting introduction, for the procedures addressed in Cutting to the Core propose to do just that — harm one's patients. However, rather than refusing to perform surgery altogether (as Hippocrates would have physicians swear), this text would have us weigh each...