SNX1 chooses its home via two membrane-binding domains. One targeting domain is the PX domain, which is known to bind to the endosomal phosphoinositide, PI3P. The second is a BAR domain, which was shown to target a fly protein to highly curved membranes and tubulate them. Cullen’s group shows that these domains combine to put mammalian SNX1 on the tubular portion of early endosomes (which also ...