Cardiovascular diseases (CVDs) are the leading cause of death and morbidity globally. The renin-angiotensin system is an important regulatory for maintaining cardiovascular renal function. Therefore, angiotensin-converting enzyme inhibitors angiotensin receptor blockers have emerged as first-line treatments conditions such hypertension heart failure. Currently available synthetic medications us...

Background and Aims: Congenital factor V (FV) deficiency is a rare bleeding disorder with 1 in 1000000 persons in the general population. Individuals with FV activity <1% and very low FV antigen levels are characterized as severe FV deficient patients. Little data is available about the molecular basis of this bleeding disorder in Iran. Materials and Methods: We analyzed 7 unrelated Iranian FV...