Fluid-to-solid phase transition in multicellular assembly is crucial many developmental biological processes, such as embryogenesis and morphogenesis. However, biomechanical studies this area are limited, little known about factors governing the how cell behaviors regulated. Due to different stresses present, cells could behave distinctively depending on nature of tissue. Here we report a fluid...

The remarkable range of biological forms in and around us, such as the undulating shape a leaf or flower garden, coils our gut, folds brain, raise number questions at interface biology, physics, mathematics. How might these shapes be predicted, how can they eventually designed? We review current understanding this problem, which brings together analysis, geometry, mechanics description morphoge...

Abstract Tissue regeneration is a process that recapitulates and restores organ structure function. Although previous studies have demonstrated wound-induced hair neogenesis (WIHN) in laboratory mice ( Mus ), the limited to center of wound unlike those observed African spiny Acomys ) mice. mechanics been implicated as an integral part tissue morphogenesis. Here, we use WIHN model investigate me...

BACKGROUND In the past decade, several transcription factors critical for pancreas organogenesis have been identified. Despite this success, many of the factors necessary for proper islet morphogenesis and function remain uncharacterized. Previous studies have shown that transgenic over-expression of the transcription factor Hnf6 specifically in the pancreatic endocrine cell lineage resulted in...

A variety of extracellular factors regulate morphogenesis during development. However, coordination between extracellular signaling and dynamic morphogenesis is largely unexplored. We address the fundamental question by studying posterior crossvein (PCV) development in Drosophila as a model, in which long-range BMP transport from the longitudinal veins plays a critical role during the pupal sta...

The morphogenetic role of the acid mucopolysaccharide (glycosaminoglycan) at the epithelial surface of mouse embryo submandibular glands has been studied by comparing the in vitro morphogenesis of epithelia from which the mucopolysaccharide was removed with that of those that retained the mucopolysaccharide. Epithelia isolated free of mesenchyme by procedures which retain the bulk of surface mu...

BACKGROUND Cell polarity genes including Crumbs (Crb) and Par complexes are essential for controlling photoreceptor morphogenesis. Among the Crb and Par complexes, Bazooka (Baz, Par-3 homolog) acts as a nodal component for other cell polarity proteins. Therefore, finding other genes interacting with Baz will help us to understand the cell polarity genes' role in photoreceptor morphogenesis. M...