motor units (mus) reflect the function of the central nervous motor system. thus, the estimated mu number is a good option to investigate the functional movement disorder in the parkinson’s disease (pd). the purpose of this study was to compare the estimated mus number in the medial gastrocnemius (mg) muscle of the normal rats and those with the parkinsonism. the mg muscle of two age-matched gr...

Motor unit number estimation (MUNE) is an electrodiagnostic procedure used to evaluate the number of motor axons connected to a muscle. All MUNE techniques rely on assumptions that must be fulfilled to produce a valid estimate. As there is no gold standard to compare the MUNE techniques against, we have developed a model of the relevant neuromuscular physiology and have used this model to simul...

All muscle contractions are dependent on the functioning of motor units. In diseases such as amyotrophic lateral sclerosis (ALS), progressive loss of motor units leads to gradual paralysis. A major difficulty in the search for a treatment for these diseases has been the lack of a reliable measure of disease progression. One possible measure would be an estimate of the number of surviving motor ...

[1] Benatar M, Hammad M, Doss-Rinev H. Concentric-needle fiber electromyografy for the diagnosis of myasthenia gravis. Muscle Nerve 2006; 34: 163–168 [2] Bischoff C. Bedeutung der Einzelfaser-Elektromyografie für die Diagnostik neuromuskulärer Erkrankungen. Klin Neurophysiol 2000; 31: 136–143 [3] Bischoff C. Einzelfaser-EMG mit konzentrischen Nadelelektrode: eine Alternative in der Diagnositik ...