conclusions it seem that melatonin due to its antioxidant properties, if added to glycerol based media, reduces the harmful effects of freezing-thawing process, and protects seminiferous tubules histological structure from oxidative injury. results the result showed that supplementation of glycerol based media with melatonin has reduced injury to histological structure of seminiferous tubules i...

background: the study of specific genes expressed in the testis is important to understanding testis development and function. spermatogenesis is an attractive model for the study of gene expression during germ cell differentiation. spermatogenesis associated-19 (spata-19) is a recently-identified important spermatogenesis-related gene specifically expressed in testis. its protein product is in...

background fluoxetine (flx), a selective serotonin reuptake inhibitor, is widely used in the treatment of neurological disorders. however, its application carries the risk of adverse reactions, including reproductive toxicities. grape seed is highly regarded for its pharmacological activities, specifically its antioxidant properties. objectives this study was designed to evaluate whether hydroa...

background: heroin as opium is being used in two pure and impure forms with known disastrous effects on different body organs including genital system. the aim of this study was to determine the changes in testosterone secretion, the percentage of fertility, changes of the body and testis weight, and gonado somatic index in mice (ballb/c). materials and methods: a total of 90 adult male and fem...

background: cytotoxic therapy can lead to prolonged azoospermia or even sterility. in the present study, we investigated the morphological changes of mouse testes after gamma-radiation. methods: after anaesthetizing of nmri mice, testes and their surrounding tissues were irradiated using a cobalt therapy machine. four experimental groups were irradiated with fractionated doses of: 1.5+8, 1.5+12...

Background: The study of specific genes expressed in the testis is important to understanding testis development and function. Spermatogenesis is an attractive model for the study of gene expression during germ cell differentiation. Spermatogenesis associated-19 (Spata-19) is a recently-identified important spermatogenesis-related gene specifically expressed in testis. Its protein product is in...

Background: In vitro spermatogenesis has a long research history beginning in the early 20th century. This organ culture method was therefore abandoned, and alternative cell culture methods were chosen by many researchers. Here, whether Tnp1, Tekt1, and Plzf, which play a crucial role in spermatogenesis, can be expressed during testis organ culture was assessed. Methods: Testes of 10 mouse pups...

background: to evaluate the radioprotective potential of punica granatum fruit rind extract (pgre) in mouse testes. materials and methods: adult male mice were divided into four groups. group i was kept without any treatment. group ii was irradiated with 8gy co60 gamma irradiation and group iii was given pgre one hour before irradiation. group iv was fed with pgre at the rate of 10 mg/kg body w...

introduction: recently, a novel gene was cloned and characterized named catsper, which codes for a unique ca2+ channel that is expressed excludively in the testis. it has crucial role in sperm motility, sperm penetration into the ovum and ultimately male fertility. in the present study, we have evaluated the expression of this gene at different ages of mouse by semi-quantitative rt-pcr. materia...

background: in most mammals, the testis is always maintained at a lower temperature than that in the abdomen, and exposure of the testis to body temperature causes degeneration of germ cells. objective: in this research, the long effect of heat exposure on sperm parameters and microstructure of mouse testis were investigated. cryptorchid mouse were induced by exposure to abdominal heat. materia...