Ongoing research into the use of messenger RNA (mRNA) vaccines for treatment cancer has been expediated by coronavirus pandemic because similar technology was used in development mRNA COVID‐19 vaccines. So how close are we now to widespread clinical anti‐cancer vaccines?

Increasing importance of vaccination during coronavirus disease 2019 (COVID-19) pandemic, several vaccines were developed. Messenger RNA (mRNA) including BNT162b2 (Pfizer, New York, NY, USA; BioNTech, Mainz, Germany), mRNA-1273 (Moderna, Cambridge, MA, USA) have been disclosed side effects such as thrombocytopenia, myocarditis and headache in general. In addition, adverse due to autoimmune resp...

Using TSG101 pre-mRNA, we previously discovered cancer-specific re-splicing of mature mRNA that generates aberrant transcripts/proteins. The fact is aberrantly re-spliced in various cancer cells implies there must be an important mechanism to prevent deleterious on the spliced normal cells. We thus postulated controlled by specific repressors, and searched for repressor candidates siRNA-based s...

objective(s): prostaglandins have been shown to mediate the gastro-protective effect of sodium hydrosulfide (nahs) but effect of nahs on mrna expression of prostaglandin e2 receptors (ep1, 3-4; eps) has not been investigated. therefore, this study designed to evaluate the effect of nahs on mrna expression of eps receptors in response to mucosal acidification and distention-induced gastric acid ...

Objective(s): Several pathological conditions are associated with hyper-production of testosterone; however, its impacts are not well understood. Hence, we evaluated the effects of supraphysiological levels of testosterone on gonadotropin-releasing hormone (GnRH) system in the hypothalamus of male rats. Also, we assessed the expression of two excitatory (kisspeptin and...

Induction of heat shock proteins (hsps) is considered as an important protective, ecophysiologically adaptive, and genetically conserved response to environmental stress in all organisms. The effects of exposure to sublethal doses of CdCl2 (0.05, 0.1 and 0.2 LC50) during 14 days on mRNA-hsp70 expression in liver and gillwere investigated in juveniles of Persian sturgeon (Acipenser persicus). Fi...

Introduction: In stroke models, Inducible Nitric Oxide Synthase (iNOS) expression initiates cellular toxicity due to excessive Nitric Oxide (NO) generation. Anchusa italica is a medicinal herb with anti-inflammatory, antioxidant and neuroprotective properties. This study evaluated the antioxidant activity and NOS mRNA expression of the Hydroalcoholic Extract Of Anchusa Italica (HEAI) in an expe...

Messenger RNA (mRNA) has come into the spotlight due to its potential for addressing a staggering number of diseases, while lack effective and safe carriers in vivo delivery significantly limits clinical application. Herein, lipid-like nanoparticles (LLNs) containing three new cholesterol derivatives achieve liver targeting mRNA is investigated. The central composite design (CCD) used tailor fo...

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