Background: Rhinitis is a prevalent chronic inflammatory disease of the nasal mucosa. Arachidonic acid-derived lipoxin A4 (LXA4) has long been recognized to exert crucial anti-inflammatory and pro-resolving effects on inflammatory responses through a specific receptor named formyl peptide receptor-2 (FPR2). This study aimed to determine the serum level of LXA4 as well as the relative mRNA expre...

background: marine natural products contain a wide range of bioactive compounds with therapeutic properties that have revealed crucial properties in the treatment of some diseases. some of these compounds have recently received considerable attention for drug discovery. in this study we examined the anti-angiogenic effect of saponin isolated from holothuria leucospilota (sea cucumber) through e...

background: liver fatty acid-binding protein (l-fabp) is the main cytosolic binding site for long chain fatty acids in hepatocytes. fabps enhance the uptake of fatty acids into the cell by increasing their concentration due to decreasing concentration of unbound fatty acids inside the cell. objectives: the aim of this study was to evaluate the effects of dietary unsaturated to saturated fatty a...

introduction: regulators of g-protein signaling protein negatively control g protein -coupled receptor signaling duration by accelerating gα subunit guanosine triphosphate hydrolysis. since regulator of g-protein signaling4 has an important role in modulating morphine effects at the cellular level and the exact mechanism(s) of adrenalectomy-induced morphine sensitization have not been fully cla...

background: il-17/il-23 axis plays an important role in the pathogenesis of several autoimmune diseases such as experimental autoimmune encephalomyelitis (eae) and multiple sclerosis (ms). the immunomodulatory properties of ginger are reported in previous studies. objective: to evaluate the effects of ginger extract on the expression of il-17 and il-23 in a model of eae. methods: eae was induce...

The study was conducted to demonstrate expression profile of cold shock protein genes; cold inducible RNA binding protein (CIRP) and RNA binding motif protein 3 (RBM3) in goats (Capra hircus) during different seasons to check the gene expression in different thermal conditions. Blood samples were collected from healthy goats of tropical and temperate region during peak winter, moderate season a...

Introduction: Maintenance of neurogenesis depends on the function of some histone-modifying enzymes; including Enhancer of zeste homolog 2 (EZH2) and histone acetyltransferases (P300). The mechanism of epigenetic regulation and gene expression underlying the transition of human umbilical cord blood mesenchymal stem cells (hUCB-MSCs) into MNs has not been fully clarified.  Methods: Two morphoge...

This study was conducted to reveal the estrogenic effects of bisphenol A and o, p’-DDT on quailembryos. Thirteen fertilized eggs were used as control (injected with 20 μl corn oil), 15 eggs were injectedwith estradiol 17β (0.04 mg dissolved in 20 μl corn oil), 20 eggs were injected with BPA (2 mg dissolved in20 μl corn oil) and 20 eggs were injected with o, p’-DDT (2 mg dissolved in 20 μl corn ...

It is well established that in addition to generating the diploid state in the zygote, the sperm also endows the oocyte with paternal centrioles, proteins and RNAs. Although the exact roles of mRNA introduced into the oocyte by the sperm are not completely understood. However, literature background, suggested that RNAs may have a vital role in embryo cleavage and further development. Therefore,...