نتایج جستجو برای: mscramms

تعداد نتایج: 40  

Journal: :Microbiology 2009
Jouko Sillanpää Sreedhar R Nallapareddy Janeu Houston Vannakambadi K Ganesh Agathe Bourgogne Kavindra V Singh Barbara E Murray Magnus Höök

We report that three (EF0089, EF2505 and EF1896, renamed here Fss1, Fss2 and Fss3, respectively, for Enterococcus faecalis surface protein) of the recently predicted MSCRAMMs (microbial surface components recognizing adhesive matrix molecules) in E. faecalis strain V583 bind fibrinogen (Fg). Despite an absence of extensive primary sequence homology, the three proteins appear to be related struc...

2016
Xiaowen Liang Brandon L. Garcia Livia Visai Sabitha Prabhakaran Nicola A. G. Meenan Jennifer R. Potts Martin J. Humphries Magnus Höök

Adherence of microbes to host tissues is a hallmark of infectious disease and is often mediated by a class of adhesins termed MSCRAMMs (Microbial Surface Components Recognizing Adhesive Matrix Molecules). Numerous pathogens express MSCRAMMs that specifically bind the heterodimeric human glycoprotein fibronectin (Fn). In addition to roles in adhesion, Fn-binding MSCRAMMs exploit physiological Fn...

Journal: :Journal of bacteriology 2003
Kathryn H Simpson Gabriela Bowden Magnus Höök Bahman Anvari

The force required to rupture bonds between individual Staphylococcus aureus MSCRAMMs and surfaces coated with extracellular matrix molecules has been quantified by using optical tweezers. The observed binding forces between fibrinogen or fibronectin and S. aureus MSCRAMMs occurred as an approximate integer multiple of 20 or 25 pN, respectively.

Journal: :Protein science : a publication of the Protein Society 2011
Krishnan Vengadesan Sthanam V L Narayana

The structural biology of Gram-positive cell surface adhesins is an emerging field of research, whereas Gram-negative pilus assembly and anchoring have been extensively investigated and are well understood. Gram-positive surface proteins known as MSCRAMMs (microbial surface components recognizing adhesive matrix molecules) and individual proteins that assemble into long, hair-like organelles kn...

2016
Srishtee Arora Anne-Catrin Uhlemann Franklin D. Lowy Magnus Hook

Coagulase negative staphylococci (CoNS) are important opportunistic pathogens. Staphylococcus epidermidis, a coagulase negative staphylococcus, is the third leading cause of nosocomial infections in the US. Surface proteins like Microbial Surface Components Recognizing Adhesive Matrix Molecules (MSCRAMMs) are major virulence factors of pathogenic gram positive bacteria. Here, we identified a ne...

2012
Hua Xiang Yue Feng Jiawei Wang Bao Liu Yeguang Chen Lei Liu Xuming Deng Maojun Yang

Staphylococcus aureus (S. aureus) pathogenesis is a complex process involving a diverse array of extracellular and cell wall components. ClfB, an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules) family surface protein, described as a fibrinogen-binding clumping factor, is a key determinant of S. aureus nasal colonization, but the molecular basis for ClfB-ligand recog...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2014
Ulrich Schwarz-Linek Mark J Banfield

The surface of Gram-positive bacteria comprises a single membrane and, typically, a thick layer of cross-linked peptidoglycan that imparts strength and rigidity. Anchored to this cell wall are protein assemblies, such as pili, and surface proteins, such as microbial surface components recognizing adhesive matrix molecules (MSCRAMMs) that act as surface adhesins. These proteins are critical not ...

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